Manoalide

Base Information

Chemical Name:Manoalide
CAS No.:75088-80-1
Molecular Formula:C25H36 O5
Molecular Weight:416.558
Hs Code.:
UNII:E1DK0157K9
DSSTox Substance ID:DTXSID401028174
Nikkaji Number:J11.639D
Wikipedia:Manoalide
Wikidata:Q10853851
ChEMBL ID:CHEMBL463914
Mol file:75088-80-1.mol

Synonyms:manoalide

Suppliers and Price of Manoalide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Manoalide
100μg
$ 155.00

Cayman Chemical
Manoalide ≥98%
1mg
$ 160.00

American Custom Chemicals Corporation
MANOALIDE 98.00%
5MG
$ 1663.75

American Custom Chemicals Corporation
MANOALIDE 98.00%
1MG
$ 337.05

Alfa Aesar
Manoalide, 98%
1mg
$ 324.00

AHH
Manoalide 98%
0.005g
$ 688.00

Total 6 raw suppliers

Chemical Property of Manoalide

Chemical Property:

Vapor Pressure:2.08E-17mmHg at 25°C
Boiling Point:609.6°C at 760 mmHg
PKA:9.75±0.40(Predicted)
Flash Point:203.3°C
PSA：75.99000
Density:1.133g/cm³
LogP:4.85500
Storage Temp.:−20°C
XLogP3:3.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:416.25627424
Heavy Atom Count:30
Complexity:783

Purity/Quality:

97% ^*data from raw suppliers

Manoalide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xn
Statements: 20/22
Safety Statements: 36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C(CCC1)(C)C)CCC(=CCCC2=CCC(OC2O)C3=CC(=O)OC3O)C
Isomeric SMILES:CC1=C(C(CCC1)(C)C)CC/C(=C/CCC2=CC[C@@H](O[C@H]2O)C3=CC(=O)O[C@H]3O)/C
Uses Manoalide is a potent inhibitor of PLC, PLA2, and calcium channel proteins.

Technology Process of Manoalide

There total 43 articles about Manoalide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 3-[(E)-4-Methyl-6-(2,6,6-trimethyl-cyclohex-1-enyl)-hex-3-enyl]-6-(5-triethylsilanyl-furan-3-yl)-5,6-dihydro-2H-pyran-2-ol

: 75088-80-1
5-Hydroxy-4-{6-hydroxy-5-[(E)-4-methyl-6-(2,6,6-trimethyl-cyclohex-1-enyl)-hex-3-enyl]-3,6-dihydro-2H-pyran-2-yl}-5H-furan-2-one

Guidance literature:: With oxygen; rose bengal; In methanol; at -80 ℃; Irradiation;
DOI:10.1039/a701936j

Reference yield: 60.0%

: 105498-76-8
seco-manoalide

: 75088-80-1
5-Hydroxy-4-{6-hydroxy-5-[(E)-4-methyl-6-(2,6,6-trimethyl-cyclohex-1-enyl)-hex-3-enyl]-3,6-dihydro-2H-pyran-2-yl}-5H-furan-2-one

Guidance literature:: In benzene; at 0 ℃; for 3h; Irradiation;
DOI:10.1016/S0040-4020(01)85353-9

Reference yield:

: 130493-22-0
5-Triethylsilyl-3-furaldehyde

: 75088-80-1
5-Hydroxy-4-{6-hydroxy-5-[(E)-4-methyl-6-(2,6,6-trimethyl-cyclohex-1-enyl)-hex-3-enyl]-3,6-dihydro-2H-pyran-2-yl}-5H-furan-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / diethyl ether

3: 94 percent / iPr₂NEt / Pd(PPh₃)4 / tetrahydrofuran; methanol / 24 h / 60 °C / 1520 Torr

4: 94 percent / DIBAL-H / CH₂Cl₂ / -80 °C

5: 60 percent / O₂, rose bengal / methanol / -80 °C / Irradiation

With oxygen; rose bengal; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1039/a701936j