2,3-dihydro-2,2-dimethyl-7-{3-[4-(2,3-dichloro-phenyl)-piperazin-1-yl]-propoxy}-benzofuran-5-sulfonic acid amide

Base Information

Chemical Name:2,3-dihydro-2,2-dimethyl-7-{3-[4-(2,3-dichloro-phenyl)-piperazin-1-yl]-propoxy}-benzofuran-5-sulfonic acid amide
CAS No.:1089209-82-4
Molecular Formula:C₂₃H₂₉Cl₂N₃O₄S
Molecular Weight:514.473
Hs Code.:

Synonyms:2,3-dihydro-2,2-dimethyl-7-{3-[4-(2,3-dichloro-phenyl)-piperazin-1-yl]-propoxy}-benzofuran-5-sulfonic acid amide

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Chemical Property of 2,3-dihydro-2,2-dimethyl-7-{3-[4-(2,3-dichloro-phenyl)-piperazin-1-yl]-propoxy}-benzofuran-5-sulfonic acid amide

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Technology Process of 2,3-dihydro-2,2-dimethyl-7-{3-[4-(2,3-dichloro-phenyl)-piperazin-1-yl]-propoxy}-benzofuran-5-sulfonic acid amide

There total 5 articles about 2,3-dihydro-2,2-dimethyl-7-{3-[4-(2,3-dichloro-phenyl)-piperazin-1-yl]-propoxy}-benzofuran-5-sulfonic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1089210-24-1
2,3-dihydro-2,2-dimethyl-7-(3-chloro-propoxy)-benzofuran-5-ylsulfonic acid amide

: 41202-77-1
1-(2,3-dichlorophenyl)piperazine

: 1089209-82-4
2,3-dihydro-2,2-dimethyl-7-{3-[4-(2,3-dichloro-phenyl)-piperazin-1-yl]-propoxy}-benzofuran-5-sulfonic acid amide

Guidance literature:: With sodium carbonate; at 160 ℃; for 2h;

Reference yield:

: 1089210-10-5
2,3-dihydro-2,2-dimethyl-7-hydroxy-benzofuran-5-sulfonic acid amide

: 1089209-82-4
2,3-dihydro-2,2-dimethyl-7-{3-[4-(2,3-dichloro-phenyl)-piperazin-1-yl]-propoxy}-benzofuran-5-sulfonic acid amide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium methylate / methanol / 14 h / Heating / reflux

2: sodium carbonate / 2 h / 160 °C

With sodium methylate; sodium carbonate; In methanol;

Reference yield:

: 1089210-09-2
7-acetoxy-2,3-dihydro-2,2-dimethyl-benzofuran-5-sulfonyl chloride

: 1089209-82-4
2,3-dihydro-2,2-dimethyl-7-{3-[4-(2,3-dichloro-phenyl)-piperazin-1-yl]-propoxy}-benzofuran-5-sulfonic acid amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonia / acetonitrile / 2 h / 5 - 10 °C / Cooling with acetone-dry ice

1.2: 2 h / Heating / reflux

2.1: sodium methylate / methanol / 14 h / Heating / reflux

3.1: sodium carbonate / 2 h / 160 °C

With ammonia; sodium methylate; sodium carbonate; In methanol; acetonitrile;