1-ethoxycarbonyl-4-{2-[5-(3-phenoxybenzyl)-1,1-dioxido-1,2,5-thiadiazolidin-2-yl]ethyl}piperazine

Base Information

Chemical Name:1-ethoxycarbonyl-4-{2-[5-(3-phenoxybenzyl)-1,1-dioxido-1,2,5-thiadiazolidin-2-yl]ethyl}piperazine
CAS No.:1357390-55-6
Molecular Formula:C₂₄H₃₂N₄O₅S
Molecular Weight:488.608
Hs Code.:

Synonyms:1-ethoxycarbonyl-4-{2-[5-(3-phenoxybenzyl)-1,1-dioxido-1,2,5-thiadiazolidin-2-yl]ethyl}piperazine

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Chemical Property of 1-ethoxycarbonyl-4-{2-[5-(3-phenoxybenzyl)-1,1-dioxido-1,2,5-thiadiazolidin-2-yl]ethyl}piperazine

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Technology Process of 1-ethoxycarbonyl-4-{2-[5-(3-phenoxybenzyl)-1,1-dioxido-1,2,5-thiadiazolidin-2-yl]ethyl}piperazine

There total 4 articles about 1-ethoxycarbonyl-4-{2-[5-(3-phenoxybenzyl)-1,1-dioxido-1,2,5-thiadiazolidin-2-yl]ethyl}piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 120-43-4
4-ethoxycarbonylpiperazine

: 1341127-10-3
2-[5-(3-phenoxybenzyl)-1,1-dioxido-1,2,5-thiadiazolidin-2-yl]ethyl methanesulfonate

: 1357390-55-6
1-ethoxycarbonyl-4-{2-[5-(3-phenoxybenzyl)-1,1-dioxido-1,2,5-thiadiazolidin-2-yl]ethyl}piperazine

Guidance literature:: With potassium carbonate; In acetonitrile; for 20h; Reflux;
DOI:10.1016/j.ejmech.2011.10.019

Reference yield:

: 1341126-59-7
2-(3-phenoxybenzyl)-1,2,5-thiadiazolidine 1,1-dioxide

: 1357390-55-6
1-ethoxycarbonyl-4-{2-[5-(3-phenoxybenzyl)-1,1-dioxido-1,2,5-thiadiazolidin-2-yl]ethyl}piperazine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; acetonitrile; mineral oil / 0.25 h

1.2: 20 °C

2.1: lithium borohydride / tetrahydrofuran; ethanol / 20 °C

3.1: triethylamine / tetrahydrofuran / 5 h / 20 °C / Cooling with ice

4.1: potassium carbonate / acetonitrile / 20 h / Reflux

With lithium borohydride; sodium hydride; potassium carbonate; triethylamine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; acetonitrile; mineral oil;
DOI:10.1016/j.ejmech.2011.10.019

Reference yield:

: 1341126-95-1
methyl [5-(3-phenoxybenzyl)-1,1-dioxido-1,2,5-thiadiazolidin-2-yl]acetate

: 1357390-55-6
1-ethoxycarbonyl-4-{2-[5-(3-phenoxybenzyl)-1,1-dioxido-1,2,5-thiadiazolidin-2-yl]ethyl}piperazine

Guidance literature:: Multi-step reaction with 3 steps

1: lithium borohydride / tetrahydrofuran; ethanol / 20 °C

2: triethylamine / tetrahydrofuran / 5 h / 20 °C / Cooling with ice

3: potassium carbonate / acetonitrile / 20 h / Reflux

With lithium borohydride; potassium carbonate; triethylamine; In tetrahydrofuran; ethanol; acetonitrile;
DOI:10.1016/j.ejmech.2011.10.019