(R,Z)-5-(5-bromo-3-methylhept-4-enylthio)-1-phenyl-1H-tetrazole

Base Information

Chemical Name:(R,Z)-5-(5-bromo-3-methylhept-4-enylthio)-1-phenyl-1H-tetrazole
CAS No.:1431611-74-3
Molecular Formula:C₁₅H₁₉BrN₄S
Molecular Weight:367.313
Hs Code.:

Synonyms:(R,Z)-5-(5-bromo-3-methylhept-4-enylthio)-1-phenyl-1H-tetrazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R,Z)-5-(5-bromo-3-methylhept-4-enylthio)-1-phenyl-1H-tetrazole

Chemical Property:

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Technology Process of (R,Z)-5-(5-bromo-3-methylhept-4-enylthio)-1-phenyl-1H-tetrazole

There total 6 articles about (R,Z)-5-(5-bromo-3-methylhept-4-enylthio)-1-phenyl-1H-tetrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1431611-61-8
(R,Z)-5-bromo-3-methylhept-4-en-1-ol

: 86-93-1
1-Phenyl-1H-tetrazole-5-thiol

: 1431611-74-3
(R,Z)-5-(5-bromo-3-methylhept-4-enylthio)-1-phenyl-1H-tetrazole

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 2h; Inert atmosphere;
DOI:10.1002/chem.201202701

Reference yield:

: 1431611-60-7
(R,Z)-5-bromo-3-methylhepta-4,6-dien-1-ol

: 1431611-74-3
(R,Z)-5-(5-bromo-3-methylhept-4-enylthio)-1-phenyl-1H-tetrazole

Guidance literature:: Multi-step reaction with 2 steps

1: potassium diazodicarboxylate; acetic acid / methanol / 6 h / 0 - 30 °C

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

With di-isopropyl azodicarboxylate; potassium diazodicarboxylate; acetic acid; triphenylphosphine; In tetrahydrofuran; methanol; 2: |Mitsunobu Displacement;
DOI:10.1002/chem.201202701

Reference yield:

: 97-65-4,25119-64-6
2-methylenesuccinic acid

: 1431611-74-3
(R,Z)-5-(5-bromo-3-methylhept-4-enylthio)-1-phenyl-1H-tetrazole

Guidance literature:: Multi-step reaction with 9 steps

1.1: acetyl chloride / 0.33 h / Reflux

2.1: catASium; hydrogen / dichloromethane / 48 h / 3000.3 Torr / Autoclave; Inert atmosphere

3.1: dimethylsulfide borane complex / tetrahydrofuran / 2.5 h / -30 - 0 °C / Inert atmosphere

4.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 0.25 h / -78 °C / Inert atmosphere

4.2: -78 - 20 °C / Inert atmosphere

5.1: triphenylphosphine; carbon tetrabromide / dichloromethane / 0 - 20 °C / Inert atmosphere

6.1: trifuran-2-yl-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 6 h / 90 °C / Inert atmosphere; Schlenk technique

7.1: diisobutylaluminium hydride / dichloromethane / 1.5 h / -78 - -40 °C / Inert atmosphere

8.1: potassium diazodicarboxylate; acetic acid / methanol / 6 h / 0 - 30 °C

9.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; oxalyl dichloride; catASium; trifuran-2-yl-phosphane; carbon tetrabromide; di-isopropyl azodicarboxylate; dimethylsulfide borane complex; hydrogen; potassium diazodicarboxylate; diisobutylaluminium hydride; acetic acid; dimethyl sulfoxide; acetyl chloride; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; toluene; 4.1: |Swern Oxidation / 4.2: |Swern Oxidation / 6.1: |Stille Cross Coupling / 9.1: |Mitsunobu Displacement;
DOI:10.1002/chem.201202701