N-(5-{3-[2-(chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amino]-propoxy}-naphthalen-1-yl)-methanesulfonamide

Base Information

Chemical Name:N-(5-{3-[2-(chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amino]-propoxy}-naphthalen-1-yl)-methanesulfonamide
CAS No.:848171-52-8
Molecular Formula:C₃₆H₃₄ClF₃N₂O₃S
Molecular Weight:667.192
Hs Code.:

Synonyms:N-(5-{3-[2-(chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amino]-propoxy}-naphthalen-1-yl)-methanesulfonamide

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Chemical Property of N-(5-{3-[2-(chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amino]-propoxy}-naphthalen-1-yl)-methanesulfonamide

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Technology Process of N-(5-{3-[2-(chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amino]-propoxy}-naphthalen-1-yl)-methanesulfonamide

There total 5 articles about N-(5-{3-[2-(chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amino]-propoxy}-naphthalen-1-yl)-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 93118-03-7
2-chloro-3-trifluoromethylbenzaldehyde

: 848171-52-8
N-(5-{3-[2-(chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amino]-propoxy}-naphthalen-1-yl)-methanesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 1.5 h / 20 °C

2: potassium carbonate / acetonitrile / 48 h / Heating / reflux

3: potassium carbonate / acetonitrile / Heating / reflux

4: trifluoroacetic acid / dichloromethane / 20 °C

5: hydrogenchloride / diethyl ether / 20 °C

6: 4-methyl-morpholine / dichloromethane / 20 °C

With 4-methyl-morpholine; hydrogenchloride; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; trifluoroacetic acid; In diethyl ether; dichloromethane; acetonitrile;

Reference yield:

: 405911-35-5
N-(2,2-diphenylethyl)-N-(2-chloro-trifluoromethylbenzyl)amine

: 848171-52-8
N-(5-{3-[2-(chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amino]-propoxy}-naphthalen-1-yl)-methanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / acetonitrile / 48 h / Heating / reflux

2: potassium carbonate / acetonitrile / Heating / reflux

3: trifluoroacetic acid / dichloromethane / 20 °C

4: hydrogenchloride / diethyl ether / 20 °C

5: 4-methyl-morpholine / dichloromethane / 20 °C

With 4-methyl-morpholine; hydrogenchloride; potassium carbonate; trifluoroacetic acid; In diethyl ether; dichloromethane; acetonitrile;

Reference yield:

: 848086-75-9
5-{3-[(2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amino]-propoxy}-naphthalen-1-ylamine

: 848171-52-8
N-(5-{3-[2-(chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amino]-propoxy}-naphthalen-1-yl)-methanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / diethyl ether / 20 °C

2: 4-methyl-morpholine / dichloromethane / 20 °C

With 4-methyl-morpholine; hydrogenchloride; In diethyl ether; dichloromethane;