(2R,3S,4S)-2-N-benzylhydroxylamine-4-tert-butoxycarbonylamino-1,5-dicyclohexyl-4N,3O-isopropylidene-3-pentanol

Base Information

Chemical Name:(2R,3S,4S)-2-N-benzylhydroxylamine-4-tert-butoxycarbonylamino-1,5-dicyclohexyl-4N,3O-isopropylidene-3-pentanol
CAS No.:219586-60-4
Molecular Formula:C₃₂H₅₂N₂O₄
Molecular Weight:528.776
Hs Code.:

Synonyms:(2R,3S,4S)-2-N-benzylhydroxylamine-4-tert-butoxycarbonylamino-1,5-dicyclohexyl-4N,3O-isopropylidene-3-pentanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3S,4S)-2-N-benzylhydroxylamine-4-tert-butoxycarbonylamino-1,5-dicyclohexyl-4N,3O-isopropylidene-3-pentanol

Chemical Property:

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Technology Process of (2R,3S,4S)-2-N-benzylhydroxylamine-4-tert-butoxycarbonylamino-1,5-dicyclohexyl-4N,3O-isopropylidene-3-pentanol

There total 5 articles about (2R,3S,4S)-2-N-benzylhydroxylamine-4-tert-butoxycarbonylamino-1,5-dicyclohexyl-4N,3O-isopropylidene-3-pentanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 35166-78-0
cyclohexylmethyl magnesium bromide

: 219586-54-6
(Z)-N-<(4S,5S)-3-tert-butoxycarbonyl-4-cyclohexylmethyl-2,2-dimethyl-5-methylenyl-1,3-oxazolidinyl>benzylamine N-oxide

: (2S,3S,4S)-2-N-benzylhydroxylamine-4-tert-butoxycarbonylamino-1,5-dicyclohexyl-4N,3O-isopropylidene-3-pentanol

: 219586-60-4
(2R,3S,4S)-2-N-benzylhydroxylamine-4-tert-butoxycarbonylamino-1,5-dicyclohexyl-4N,3O-isopropylidene-3-pentanol

Guidance literature:: With diethylaluminium chloride; In tetrahydrofuran; diethyl ether; hexane; at -78 ℃; for 3h; Yield given; Yields of byproduct given;
DOI:10.1021/jo980980u

Reference yield:

: 127306-04-1
(4S,5S)-3-[(tert-butyloxy)carbonyl]-4-(cyclohexylmethyl)-2,2-dimethyloxazolidine-5-carboxaldehyde

: 219586-60-4
(2R,3S,4S)-2-N-benzylhydroxylamine-4-tert-butoxycarbonylamino-1,5-dicyclohexyl-4N,3O-isopropylidene-3-pentanol

Guidance literature:: Multi-step reaction with 2 steps

1: MgSO₄ / CH₂Cl₂ / 0.5 h / Ambient temperature

2: Et₂AlCl / diethyl ether; tetrahydrofuran; hexane / 3 h / -78 °C

With diethylaluminium chloride; magnesium sulfate; In tetrahydrofuran; diethyl ether; hexane; dichloromethane;
DOI:10.1021/jo980980u

Reference yield:

: 622-30-0
N-benzyl hydroxylalmine

: 219586-60-4
(2R,3S,4S)-2-N-benzylhydroxylamine-4-tert-butoxycarbonylamino-1,5-dicyclohexyl-4N,3O-isopropylidene-3-pentanol

Guidance literature:: Multi-step reaction with 2 steps

1: MgSO₄ / CH₂Cl₂ / 0.5 h / Ambient temperature

2: Et₂AlCl / diethyl ether; tetrahydrofuran; hexane / 3 h / -78 °C

With diethylaluminium chloride; magnesium sulfate; In tetrahydrofuran; diethyl ether; hexane; dichloromethane;
DOI:10.1021/jo980980u