[(4R,5R)-5-Isobutoxy-1-(4-methoxy-benzylcarbamoyl)-azepan-4-yl]-((E)-(R)-2-methyl-4-phenyl-but-3-enyl)-carbamic acid tert-butyl ester

Base Information

Chemical Name:[(4R,5R)-5-Isobutoxy-1-(4-methoxy-benzylcarbamoyl)-azepan-4-yl]-((E)-(R)-2-methyl-4-phenyl-but-3-enyl)-carbamic acid tert-butyl ester
CAS No.:392724-92-4
Molecular Formula:C₃₅H₅₁N₃O₅
Molecular Weight:593.807
Hs Code.:

Synonyms:[(4R,5R)-5-Isobutoxy-1-(4-methoxy-benzylcarbamoyl)-azepan-4-yl]-((E)-(R)-2-methyl-4-phenyl-but-3-enyl)-carbamic acid tert-butyl ester

Suppliers and Price of [(4R,5R)-5-Isobutoxy-1-(4-methoxy-benzylcarbamoyl)-azepan-4-yl]-((E)-(R)-2-methyl-4-phenyl-but-3-enyl)-carbamic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of [(4R,5R)-5-Isobutoxy-1-(4-methoxy-benzylcarbamoyl)-azepan-4-yl]-((E)-(R)-2-methyl-4-phenyl-but-3-enyl)-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of [(4R,5R)-5-Isobutoxy-1-(4-methoxy-benzylcarbamoyl)-azepan-4-yl]-((E)-(R)-2-methyl-4-phenyl-but-3-enyl)-carbamic acid tert-butyl ester

There total 14 articles about [(4R,5R)-5-Isobutoxy-1-(4-methoxy-benzylcarbamoyl)-azepan-4-yl]-((E)-(R)-2-methyl-4-phenyl-but-3-enyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 392724-90-2
(4R,5R)-4-[((S)-3-Benzyloxy-2-methyl-propyl)-tert-butoxycarbonyl-amino]-5-isobutoxy-azepane-1-carboxylic acid 2-trimethylsilanyl-ethyl ester

: 392724-92-4
[(4R,5R)-5-Isobutoxy-1-(4-methoxy-benzylcarbamoyl)-azepan-4-yl]-((E)-(R)-2-methyl-4-phenyl-but-3-enyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 91 percent / H₂ / Pd/C / methanol / 12 h / 20 °C

2.1: Dess-Martin periodinane; pyridine / CH₂Cl₂ / 0.5 h / 20 °C

3.1: n-BuLi / benzene; hexane / 1 h / 20 °C

3.2: 94 percent / benzene; hexane / 5 h / 20 °C

4.1: TBAF / tetrahydrofuran / 12 h / 20 °C

5.1: 92.8 mg / tetrahydrofuran / 2 h

With pyridine; n-butyllithium; tetrabutyl ammonium fluoride; hydrogen; Dess-Martin periodane; palladium on activated charcoal; In tetrahydrofuran; methanol; hexane; dichloromethane; benzene; 2.1: Dess-Martin oxidation / 3.1: Wittig reaction;
DOI:10.1021/ol016799g

Reference yield:

: (1S,7R)-8-Oxa-4-aza-bicyclo[5.1.0]octane-4-carboxylic acid 2-trimethylsilanyl-ethyl ester

: 392724-92-4
[(4R,5R)-5-Isobutoxy-1-(4-methoxy-benzylcarbamoyl)-azepan-4-yl]-((E)-(R)-2-methyl-4-phenyl-but-3-enyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: azidotrimethylsilane / (S,S)-Jacobsen Cr(salen) catalyst / diethyl ether / 144 h

1.2: 1S-(+)-10-camphorsulfuric acid / methanol / 0.5 h

2.1: NaH / tetrahydrofuran / 0.5 h / 20 °C

2.2: 88 percent / tetramethylammonium iodide / tetrahydrofuran / 0.5 h / 20 °C

3.1: 98 percent / H₂ / Pd/C / methanol / 12 h / 20 °C

4.1: 73 percent / NaBH₃CN; molecular sieves 4 Angstroem / methanol; acetic acid / 1 h / 20 °C / pH 6 - 7

5.1: 81 percent / Et₃N / CH₂Cl₂ / 12 h / 20 °C

6.1: 91 percent / H₂ / Pd/C / methanol / 12 h / 20 °C

7.1: Dess-Martin periodinane; pyridine / CH₂Cl₂ / 0.5 h / 20 °C

8.1: n-BuLi / benzene; hexane / 1 h / 20 °C

8.2: 94 percent / benzene; hexane / 5 h / 20 °C

9.1: TBAF / tetrahydrofuran / 12 h / 20 °C

10.1: 92.8 mg / tetrahydrofuran / 2 h

With pyridine; n-butyllithium; trimethylsilylazide; 4 A molecular sieve; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; sodium cyanoborohydride; Dess-Martin periodane; triethylamine; palladium on activated charcoal; (S,S)-Jacobsen Cr(salen) catalyst; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; acetic acid; benzene; 7.1: Dess-Martin oxidation / 8.1: Wittig reaction;
DOI:10.1021/ol016799g

Reference yield:

: 132365-02-7
N-benzyl-N-(but-3-enyl)-but-3-en-1-amine

: 392724-92-4
[(4R,5R)-5-Isobutoxy-1-(4-methoxy-benzylcarbamoyl)-azepan-4-yl]-((E)-(R)-2-methyl-4-phenyl-but-3-enyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 13 steps

1.1: 58 percent / tetrahydrofuran / 12 h / 20 °C

2.1: 90 percent / (benzylidene)Ru(PCy₃)2Cl₂ / CH₂Cl₂ / 24 h / Heating

3.1: 83 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 12 h / 0 °C

4.1: azidotrimethylsilane / (S,S)-Jacobsen Cr(salen) catalyst / diethyl ether / 144 h

4.2: 1S-(+)-10-camphorsulfuric acid / methanol / 0.5 h

5.1: NaH / tetrahydrofuran / 0.5 h / 20 °C

5.2: 88 percent / tetramethylammonium iodide / tetrahydrofuran / 0.5 h / 20 °C

6.1: 98 percent / H₂ / Pd/C / methanol / 12 h / 20 °C

7.1: 73 percent / NaBH₃CN; molecular sieves 4 Angstroem / methanol; acetic acid / 1 h / 20 °C / pH 6 - 7

8.1: 81 percent / Et₃N / CH₂Cl₂ / 12 h / 20 °C

9.1: 91 percent / H₂ / Pd/C / methanol / 12 h / 20 °C

10.1: Dess-Martin periodinane; pyridine / CH₂Cl₂ / 0.5 h / 20 °C

11.1: n-BuLi / benzene; hexane / 1 h / 20 °C

11.2: 94 percent / benzene; hexane / 5 h / 20 °C

12.1: TBAF / tetrahydrofuran / 12 h / 20 °C

13.1: 92.8 mg / tetrahydrofuran / 2 h

With pyridine; n-butyllithium; trimethylsilylazide; 4 A molecular sieve; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; sodium cyanoborohydride; Dess-Martin periodane; triethylamine; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; Grubbs catalyst first generation; (S,S)-Jacobsen Cr(salen) catalyst; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; acetic acid; benzene; 10.1: Dess-Martin oxidation / 11.1: Wittig reaction;
DOI:10.1021/ol016799g