Technology Process of (5S,11S,13aR)-5-Benzyl-8,8-dimethyl-11-((E)-oct-6-enyl)-decahydro-3a,6,9,12-tetraaza-cyclopentacyclododecene-4,7,10,13-tetraone
There total 12 articles about (5S,11S,13aR)-5-Benzyl-8,8-dimethyl-11-((E)-oct-6-enyl)-decahydro-3a,6,9,12-tetraaza-cyclopentacyclododecene-4,7,10,13-tetraone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
DOI:10.1016/S0040-4039(01)00139-3
- Guidance literature:
-
Multi-step reaction with 11 steps
1: LiAlH4 / bis-(2-methoxy-ethyl) ether; tetrahydrofuran
2: TEA / CH2Cl2
3: LiI / diethyl ether
4: n-BuLi / tetrahydrofuran / -78 - 20 °C
5: HCl / H2O / 20 °C
6: DIEA / CH2Cl2 / 20 °C
7: LiOH / 1,2-dimethoxy-ethane; H2O / 20 °C
8: 78 percent / PyBOP<*>; DIEA / CH2Cl2 / 20 °C
9: LiOH / 1,2-dimethoxy-ethane; H2O / 20 °C
10: TFA / CH2Cl2
11: PyBOP<*>; DIEA / CH2Cl2
With
hydrogenchloride; lithium hydroxide; lithium aluminium tetrahydride; n-butyllithium; TEA; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium iodide;
In
tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; dichloromethane; diethylene glycol dimethyl ether; water;
4: Schoellkopf amino acid synthesis;
DOI:10.1016/S0040-4039(01)00139-3
- Guidance literature:
-
Multi-step reaction with 10 steps
1: TEA / CH2Cl2
2: LiI / diethyl ether
3: n-BuLi / tetrahydrofuran / -78 - 20 °C
4: HCl / H2O / 20 °C
5: DIEA / CH2Cl2 / 20 °C
6: LiOH / 1,2-dimethoxy-ethane; H2O / 20 °C
7: 78 percent / PyBOP<*>; DIEA / CH2Cl2 / 20 °C
8: LiOH / 1,2-dimethoxy-ethane; H2O / 20 °C
9: TFA / CH2Cl2
10: PyBOP<*>; DIEA / CH2Cl2
With
hydrogenchloride; lithium hydroxide; n-butyllithium; TEA; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium iodide;
In
tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; dichloromethane; water;
3: Schoellkopf amino acid synthesis;
DOI:10.1016/S0040-4039(01)00139-3
![(R)-1-{(S)-2-[2-((E)-(S)-2-Amino-dec-8-enoylamino)-2-methyl-propionylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid](/Databaselist/images/loading.webp)
