N-(3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)-4-chloro-3-(trifluoromethyl)benzamide

Base Information

Chemical Name:N-(3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)-4-chloro-3-(trifluoromethyl)benzamide
CAS No.:1173701-49-9
Molecular Formula:C₂₀H₁₃ClF₃N₅O
Molecular Weight:431.804
Hs Code.:

Synonyms:N-(3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)-4-chloro-3-(trifluoromethyl)benzamide

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Chemical Property of N-(3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)-4-chloro-3-(trifluoromethyl)benzamide

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Technology Process of N-(3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)-4-chloro-3-(trifluoromethyl)benzamide

There total 7 articles about N-(3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)-4-chloro-3-(trifluoromethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 1737-36-6
4-chloro-3-(trifluoromethyl)benzoic acid

: 1173701-35-3
4-amino-7-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidine

: 1173701-49-9
N-(3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)-4-chloro-3-(trifluoromethyl)benzamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 0 - 80 ℃; for 24h; Inert atmosphere;
DOI:10.1248/cpb.c13-00249

Reference yield:

: 74895-37-7
2-Cyan-4,4-diethoxybuttersaeurenitril

: 1173701-49-9
N-(3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)-4-chloro-3-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 7 steps

1: potassium tert-butylate / ethanol / 0 °C / Reflux

2: hydrogenchloride / water / 1.17 h / 50 °C

3: Raney-Nickel / water / 4 h / Reflux

4: pyridine / 50 °C

5: potassium carbonate; copper(l) iodide; L-proline / dimethyl sulfoxide / 40 h / 90 °C / Inert atmosphere

6: tin(II) chloride hydrate / ethanol / Reflux

7: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 24 h / 0 - 80 °C / Inert atmosphere

With pyridine; hydrogenchloride; copper(l) iodide; tin(II) chloride hydrate; potassium tert-butylate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; L-proline; In ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1248/cpb.c13-00249

Reference yield:

: 4,6-diamino-5-(2,2-diethoxyethyl)pyrimidine-2-thiol potassium salt

: 1173701-49-9
N-(3-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)-4-chloro-3-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogenchloride / water / 1.17 h / 50 °C

2: Raney-Nickel / water / 4 h / Reflux

3: pyridine / 50 °C

4: potassium carbonate; copper(l) iodide; L-proline / dimethyl sulfoxide / 40 h / 90 °C / Inert atmosphere

5: tin(II) chloride hydrate / ethanol / Reflux

6: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 24 h / 0 - 80 °C / Inert atmosphere

With pyridine; hydrogenchloride; copper(l) iodide; tin(II) chloride hydrate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; L-proline; In ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1248/cpb.c13-00249