3'-amino-5'-O-(4,4'-dimethoxytrityl)-N₂-isobutyryl-2',3'-dideoxyguanosine

Base Information

Chemical Name:3'-amino-5'-O-(4,4'-dimethoxytrityl)-N₂-isobutyryl-2',3'-dideoxyguanosine
CAS No.:170236-30-3
Molecular Formula:C₃₅H₃₈N₆O₆
Molecular Weight:638.723
Hs Code.:

3'-amino-5'-O-(4,4'-dimethoxytrityl)-N<sub>2</sub>-isobutyryl-2',3'-dideoxyguanosine

Synonyms:3'-amino-5'-O-(4,4'-dimethoxytrityl)-N₂-isobutyryl-2',3'-dideoxyguanosine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3'-amino-5'-O-(4,4'-dimethoxytrityl)-N₂-isobutyryl-2',3'-dideoxyguanosine

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Technology Process of 3'-amino-5'-O-(4,4'-dimethoxytrityl)-N₂-isobutyryl-2',3'-dideoxyguanosine

There total 2 articles about 3'-amino-5'-O-(4,4'-dimethoxytrityl)-N₂-isobutyryl-2',3'-dideoxyguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 170236-41-6
3'-azido-5'-O-(4,4'-dimethoxytrityl)-N₂-isobutyryl-2',3'-dideoxyguanosine

: 170236-30-3
3'-amino-5'-O-(4,4'-dimethoxytrityl)-N₂-isobutyryl-2',3'-dideoxyguanosine

Guidance literature:: With palladium on activated charcoal; hydrogen; sodium hydrogencarbonate; In ethanol; water; for 6h;
DOI:10.1021/jo8018889

Reference yield:

: 719288-80-9
N²-isobutyryl-5'-(4,4'-dimethoxytrityl)-3'-mesyl-2',3'-dideoxyxyloguanosine

: 170236-30-3
3'-amino-5'-O-(4,4'-dimethoxytrityl)-N₂-isobutyryl-2',3'-dideoxyguanosine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium azide / dimethyl sulfoxide / 90 °C

2: hydrogen / palladium / ethanol / 4 h / 20 °C

With sodium azide; hydrogen; palladium; In ethanol; dimethyl sulfoxide;

Reference yield:

: 198637-74-0
2-chloro-“spiro”-4,4-pentamethylene-1,3,2-oxathiaphospholane

: 170236-30-3
3'-amino-5'-O-(4,4'-dimethoxytrityl)-N₂-isobutyryl-2',3'-dideoxyguanosine

: N-{9-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(2-oxo-3-oxa-1-thia-2λ⁵-phospha-spiro[4.5]dec-2-ylamino)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-isobutyramide

Guidance literature:: With tert.-butylhydroperoxide; N-ethyl-N,N-diisopropylamine; Yield given; Multistep reaction; 1.) MeCN, room temperature, 2 h, 2.) C₆H₆, room temperature, 1 h;
DOI:10.1021/jo982240r