(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanethioamide hydrosulfate

Base Information

Chemical Name:(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanethioamide hydrosulfate
CAS No.:1175536-51-2
Molecular Formula:C₁₃H₁₄F₂N₄OS*H₂O₄S
Molecular Weight:410.423
Hs Code.:

Synonyms:(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanethioamide hydrosulfate

Suppliers and Price of (2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanethioamide hydrosulfate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of (2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanethioamide hydrosulfate

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Hazard Codes:

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Technology Process of (2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanethioamide hydrosulfate

There total 1 articles about (2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanethioamide hydrosulfate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.2%

: 170862-36-9
(2S,3R)-3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanenitrile

: 1175536-51-2
(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanethioamide hydrosulfate

Guidance literature:: (2S,3R)-3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanenitrile; With O,O-Diethyl hydrogen phosphorodithioate; In water; isopropyl alcohol; at 75 - 80 ℃; for 9h; Large scale reaction;

With sodium hydroxide; In water; ethyl acetate; isopropyl alcohol; at 10 - 20 ℃; pH=8.1; Large scale reaction;

With sulfuric acid; In ethyl acetate; isopropyl alcohol; at 23 - 40 ℃; Large scale reaction;
DOI:10.1021/op900065c

Reference yield: 85.8%

: 1175536-51-2
(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanethioamide hydrosulfate

: 20099-89-2
4-Cyanophenacyl bromide

: 182760-06-1
ravuconazole

Guidance literature:: (2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanethioamide hydrosulfate; 4-Cyanophenacyl bromide; In ethanol; water; at 60 - 70 ℃; for 2h; Large scale reaction;

With triethylamine; In ethanol; water; at 55 - 70 ℃; pH=3.5 - 4; Large scale reaction;
DOI:10.1021/op900065c