N-{3-[5-(3-bromo-5-isopropoxy-phenyl)oxazol-2-ylamino]-4-methyl-phenyl}-N-thiazol-2-yl-acetamide

Base Information

Chemical Name:N-{3-[5-(3-bromo-5-isopropoxy-phenyl)oxazol-2-ylamino]-4-methyl-phenyl}-N-thiazol-2-yl-acetamide
CAS No.:1420998-39-5
Molecular Formula:C₂₄H₂₃BrN₄O₃S
Molecular Weight:527.442
Hs Code.:

Synonyms:N-{3-[5-(3-bromo-5-isopropoxy-phenyl)oxazol-2-ylamino]-4-methyl-phenyl}-N-thiazol-2-yl-acetamide

Suppliers and Price of N-{3-[5-(3-bromo-5-isopropoxy-phenyl)oxazol-2-ylamino]-4-methyl-phenyl}-N-thiazol-2-yl-acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-{3-[5-(3-bromo-5-isopropoxy-phenyl)oxazol-2-ylamino]-4-methyl-phenyl}-N-thiazol-2-yl-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-{3-[5-(3-bromo-5-isopropoxy-phenyl)oxazol-2-ylamino]-4-methyl-phenyl}-N-thiazol-2-yl-acetamide

There total 10 articles about N-{3-[5-(3-bromo-5-isopropoxy-phenyl)oxazol-2-ylamino]-4-methyl-phenyl}-N-thiazol-2-yl-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1420998-10-2
5-(3-bromo-5-isopropoxy-phenyl)-2-chloro-oxazole

: 1420998-38-4
N-[5-(acetyl-thiazol-2-yl-amino)-2-methyl-phenyl]acetamide

: 1420998-39-5
N-{3-[5-(3-bromo-5-isopropoxy-phenyl)oxazol-2-ylamino]-4-methyl-phenyl}-N-thiazol-2-yl-acetamide

Guidance literature:: N-[5-(acetyl-thiazol-2-yl-amino)-2-methyl-phenyl]acetamide; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 1h;

5-(3-bromo-5-isopropoxy-phenyl)-2-chloro-oxazole; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 16h;

Reference yield:

: 1420998-08-8
5-(3-bromo-5-isopropoxy-phenyl)oxazole

: 1420998-39-5
N-{3-[5-(3-bromo-5-isopropoxy-phenyl)oxazol-2-ylamino]-4-methyl-phenyl}-N-thiazol-2-yl-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

1.2: 16 h / -78 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 20 °C

2.2: 16 h / 0 - 20 °C

With sodium hydride; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1112210-82-8
1,3-dibromo-5-isopropoxy-benzene

: 1420998-39-5
N-{3-[5-(3-bromo-5-isopropoxy-phenyl)oxazol-2-ylamino]-4-methyl-phenyl}-N-thiazol-2-yl-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / diethyl ether / 0.5 h / -78 °C / Inert atmosphere

1.2: 1.5 h / -78 - -40 °C

2.1: potassium carbonate / methanol / 16 h / 20 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

3.2: 16 h / -78 - 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 20 °C

4.2: 16 h / 0 - 20 °C

With n-butyllithium; sodium hydride; potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; diethyl ether; N,N-dimethyl-formamide; mineral oil;