3-amino-6-(4-fluorophenyl)-5-trifluoromethylpyridine-2-carboxylic acid ((S)-3,3,3-trifluoro-2-hydroxy-2-methylpropyl)amide

Base Information

Chemical Name:3-amino-6-(4-fluorophenyl)-5-trifluoromethylpyridine-2-carboxylic acid ((S)-3,3,3-trifluoro-2-hydroxy-2-methylpropyl)amide
CAS No.:1334546-80-3
Molecular Formula:C₁₇H₁₄F₇N₃O₂
Molecular Weight:425.306
Hs Code.:

Synonyms:3-amino-6-(4-fluorophenyl)-5-trifluoromethylpyridine-2-carboxylic acid ((S)-3,3,3-trifluoro-2-hydroxy-2-methylpropyl)amide

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Chemical Property of 3-amino-6-(4-fluorophenyl)-5-trifluoromethylpyridine-2-carboxylic acid ((S)-3,3,3-trifluoro-2-hydroxy-2-methylpropyl)amide

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Technology Process of 3-amino-6-(4-fluorophenyl)-5-trifluoromethylpyridine-2-carboxylic acid ((S)-3,3,3-trifluoro-2-hydroxy-2-methylpropyl)amide

There total 10 articles about 3-amino-6-(4-fluorophenyl)-5-trifluoromethylpyridine-2-carboxylic acid ((S)-3,3,3-trifluoro-2-hydroxy-2-methylpropyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1334546-74-5
3-amino-6-bromo-5-trifluoromethylpyridine-2-carboxylic acid ((S)-3,3,3-trifluoro-2-hydroxy-2-methylpropyl)amide

: 1765-93-1
4-fluoroboronic acid

: 1334546-80-3
3-amino-6-(4-fluorophenyl)-5-trifluoromethylpyridine-2-carboxylic acid ((S)-3,3,3-trifluoro-2-hydroxy-2-methylpropyl)amide

Guidance literature:: With caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; at 160 ℃; for 0.25h; Microwave irradiation; Inert atmosphere; Sealed tube;

Reference yield:

: 866775-16-8
3-nitro-5-trifluoromethyl-pyridine-2-carbonitrile

: 1334546-80-3
3-amino-6-(4-fluorophenyl)-5-trifluoromethylpyridine-2-carboxylic acid ((S)-3,3,3-trifluoro-2-hydroxy-2-methylpropyl)amide

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 18 h / Inert atmosphere

2.1: hydrogenchloride; water / 24 h / Reflux

3.1: sulfuric acid / 48 h / Reflux

3.2: 20 °C

4.1: bromine; sulfuric acid; acetic acid / water / 20 h / 20 °C

5.1: sodium hydroxide; water / methanol / 20 °C

6.1: HATU / N,N-dimethyl-formamide / 0.03 h / 20 °C

6.2: 3 h / 20 °C

7.1: Chiralpak OJ-H / isopropyl alcohol; diethylamine; carbon dioxide / Resolution of racemate

8.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran / 0.25 h / 160 °C / Microwave irradiation; Inert atmosphere; Sealed tube

With hydrogenchloride; sulfuric acid; water; hydrogen; bromine; caesium carbonate; acetic acid; HATU; sodium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; carbon dioxide; water; ethyl acetate; diethylamine; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1214336-90-9
3-amino-6-(2,6-difluorophenyl)-5-trifluoromethyl-2-pyridinecarboxylicacid

: 1334546-80-3
3-amino-6-(4-fluorophenyl)-5-trifluoromethylpyridine-2-carboxylic acid ((S)-3,3,3-trifluoro-2-hydroxy-2-methylpropyl)amide

Guidance literature:: Multi-step reaction with 9 steps

1.1: tetrabutylammomium bromide / toluene / 10 h / Reflux

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 18 h / Inert atmosphere

3.1: hydrogenchloride; water / 24 h / Reflux

4.1: sulfuric acid / 48 h / Reflux

4.2: 20 °C

5.1: bromine; sulfuric acid; acetic acid / water / 20 h / 20 °C

6.1: sodium hydroxide; water / methanol / 20 °C

7.1: HATU / N,N-dimethyl-formamide / 0.03 h / 20 °C

7.2: 3 h / 20 °C

8.1: Chiralpak OJ-H / isopropyl alcohol; diethylamine; carbon dioxide / Resolution of racemate

9.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran / 0.25 h / 160 °C / Microwave irradiation; Inert atmosphere; Sealed tube

With hydrogenchloride; sulfuric acid; tetrabutylammomium bromide; water; hydrogen; bromine; caesium carbonate; acetic acid; HATU; sodium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; carbon dioxide; water; ethyl acetate; diethylamine; N,N-dimethyl-formamide; isopropyl alcohol; toluene;