5,7-bis-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxymethyl)-3-hydroxy-4-methyl-heptanal

Base Information

Chemical Name:5,7-bis-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxymethyl)-3-hydroxy-4-methyl-heptanal
CAS No.:911837-47-3
Molecular Formula:C₃₇H₆₄O₅Si₃
Molecular Weight:673.169
Hs Code.:

5,7-bis-(<i>tert</i>-butyl-dimethyl-silanyloxy)-2-(<i>tert</i>-butyl-diphenyl-silanyloxymethyl)-3-hydroxy-4-methyl-heptanal

Synonyms:5,7-bis-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxymethyl)-3-hydroxy-4-methyl-heptanal

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Chemical Property of 5,7-bis-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxymethyl)-3-hydroxy-4-methyl-heptanal

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Technology Process of 5,7-bis-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxymethyl)-3-hydroxy-4-methyl-heptanal

There total 8 articles about 5,7-bis-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxymethyl)-3-hydroxy-4-methyl-heptanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 911837-35-9
6,8-bis-(tert-butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxymethyl)-5-methyl-oct-1-en-4-ol

: 911837-47-3
5,7-bis-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxymethyl)-3-hydroxy-4-methyl-heptanal

Guidance literature:: With sodium periodate; osmium(VIII) oxide; N-methyl-2-indolinone; In water; tert-butyl alcohol;
DOI:10.1016/j.tetlet.2006.06.173

Reference yield:

: 911837-33-7
(2R,3S)-3,5-bis(tert-butyldimethylsilyloxy)-2-methylpentanal

: 911837-47-3
5,7-bis-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxymethyl)-3-hydroxy-4-methyl-heptanal

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / Bu₂BOTf; Et₃N

2: 93 percent / NaBH₄ / tetrahydrofuran; H₂O

3: 95 percent / 4-DMAP; pyridine / CH₂Cl₂; dimethylformamide

4: 80 percent / OsO₄; NMO; NaIO₄ / 2-methyl-propan-2-ol; H₂O

With pyridine; dmap; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; N-methyl-2-indolinone; di-n-butylboryl trifluoromethanesulfonate; triethylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol; 1: Evans aldol condensation;
DOI:10.1016/j.tetlet.2006.06.173

Reference yield:

: 911837-46-2
(2S,3R,4S,5S)-5,7-Bis-(tert-butyl-dimethyl-silanyloxy)-4-methyl-2-vinyl-heptane-1,3-diol

: 911837-47-3
5,7-bis-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxymethyl)-3-hydroxy-4-methyl-heptanal

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / 4-DMAP; pyridine / CH₂Cl₂; dimethylformamide

2: 80 percent / OsO₄; NMO; NaIO₄ / 2-methyl-propan-2-ol; H₂O

With pyridine; dmap; sodium periodate; osmium(VIII) oxide; N-methyl-2-indolinone; In dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.tetlet.2006.06.173