(E)-2,2-dimethyl-N-tosyl-5-(triisopropylsilyl)pent-3-enamide

Base Information

• Chemical Name: (E)-2,2-dimethyl-N-tosyl-5-(triisopropylsilyl)pent-3-enamide
• CAS No.: 1411043-63-4
• Molecular Formula: C₂₃H₃₉NO₃SSi
• Molecular Weight: 437.719
• Mol file: 1411043-63-4.mol

Synonyms:(E)-2,2-dimethyl-N-tosyl-5-(triisopropylsilyl)pent-3-enamide

Chemical Property of (E)-2,2-dimethyl-N-tosyl-5-(triisopropylsilyl)pent-3-enamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-2,2-dimethyl-N-tosyl-5-(triisopropylsilyl)pent-3-enamide

There total 1 articles about (E)-2,2-dimethyl-N-tosyl-5-(triisopropylsilyl)pent-3-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

(E)-2,2-dimethyl-5-(triisopropylsilyl)pent-3-enoic acid (1193511-18-0) + Tosyl isocyanate (4083-64-1) → (E)-2,2-dimethyl-N-tosyl-5-(triisopropylsilyl)pent-3-enamide (1411043-63-4)

Guidance literature:

(E)-2,2-dimethyl-5-(triisopropylsilyl)pent-3-enoic acid; Tosyl isocyanate; In tetrahydrofuran; at 20 ℃; for 0.166667h; Inert atmosphere;

With triethylamine; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.jfluchem.2012.05.013

Reference yield:

(E)-2,2-dimethyl-N-tosyl-5-(triisopropylsilyl)pent-3-enamide (1411043-63-4) → (E)-N-(2,2-dimethyl-5-(triisopropylsilyl)pent-3-en-1-yl)-4-methylbenzenesulfonamide (1411043-65-6) + (Z)-N-(2,2-dimethyl-5-(triisopropylsilyl)pent-3-en-1-yl)-4-methylbenzenesulfonamide (1411043-67-8)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 0 - 20 ℃; Overall yield = 48 %; Overall yield = 90.3 mg; Inert atmosphere;

DOI:10.1016/j.jfluchem.2012.05.013

upstream raw materials:

(E)-2,2-dimethyl-5-(triisopropylsilyl)pent-3-enoic acid

Tosyl isocyanate

Downstream raw materials:

(E)-N-(2,2-dimethyl-5-(triisopropylsilyl)pent-3-en-1-yl)-4-methylbenzenesulfonamide

(Z)-N-(2,2-dimethyl-5-(triisopropylsilyl)pent-3-en-1-yl)-4-methylbenzenesulfonamide