(R)-1-<(tert-butoxycarbonyl)amino>-2-hydroxy-3-<<(4-methylphenyl)sulfonyl>oxy>propane

Base Information

• Chemical Name: (R)-1-<(tert-butoxycarbonyl)amino>-2-hydroxy-3-<<(4-methylphenyl)sulfonyl>oxy>propane
• CAS No.: 148983-24-8
• Molecular Formula: C₁₅H₂₃NO₆S
• Molecular Weight: 345.417
• Mol file: 148983-24-8.mol

Synonyms:(R)-1-<(tert-butoxycarbonyl)amino>-2-hydroxy-3-<<(4-methylphenyl)sulfonyl>oxy>propane

Chemical Property of (R)-1-<(tert-butoxycarbonyl)amino>-2-hydroxy-3-<<(4-methylphenyl)sulfonyl>oxy>propane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-1-<(tert-butoxycarbonyl)amino>-2-hydroxy-3-<<(4-methylphenyl)sulfonyl>oxy>propane

There total 3 articles about (R)-1-<(tert-butoxycarbonyl)amino>-2-hydroxy-3-<<(4-methylphenyl)sulfonyl>oxy>propane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

p-toluenesulfonyl chloride (98-59-9) + (R)-1-<(tert-butoxycarbonyl)amino>-2,3-dihydroxypropane (148983-23-7) → (R)-1-<(tert-butoxycarbonyl)amino>-2-hydroxy-3-<<(4-methylphenyl)sulfonyl>oxy>propane (148983-24-8)

Guidance literature:

With pyridine; for 3h; Ambient temperature;

DOI:10.1021/jm00048a007

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → (R)-1-<(tert-butoxycarbonyl)amino>-2-hydroxy-3-<<(4-methylphenyl)sulfonyl>oxy>propane (148983-24-8)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH / dioxane / 18 h / Ambient temperature

2: 62 percent / pyridine / 3 h / Ambient temperature

With pyridine; sodium hydroxide; In 1,4-dioxane;

DOI:10.1021/jm00048a007

Reference yield:

p-toluenesulfonyl chloride (98-59-9) + (R)-1-<(tert-butoxycarbonyl)amino>-2,3-dihydroxypropane (148983-23-7) → C22H29NO8S2 + (R)-1-<(tert-butoxycarbonyl)amino>-2-hydroxy-3-<<(4-methylphenyl)sulfonyl>oxy>propane (148983-24-8)

Guidance literature:

With pyridine; at -10 - 20 ℃; for 19.5h;

DOI:10.1002/chem.200901789

upstream raw materials:

p-toluenesulfonyl chloride

(R)-1-<(tert-butoxycarbonyl)amino>-2,3-dihydroxypropane

di-tert-butyl dicarbonate

Downstream raw materials:

(R)-<<(tert-butoxycarbonyl)amino>methyl>oxirane