Harmine Hydrochloride

Base Information

• Chemical Name: Harmine Hydrochloride
• CAS No.: 343-27-1
• Molecular Formula: C13H13ClN2O
• Molecular Weight: 248.71
• Hs Code.: 29339900
• European Community (EC) Number: 206-443-8
• NSC Number: 29844
• UNII: T89I34ODAA
• DSSTox Substance ID: DTXSID7052024
• Wikidata: Q27289808
• ChEMBL ID: CHEMBL1593867
• Mol file: 343-27-1.mol

Synonyms:Harmine Hydrochloride;343-27-1;7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole hydrochloride;HARMINE HCl;Harmine monohydrochloride;Harmine (hydrochloride);CCRIS 7889;telepathine hydrochloride;EINECS 206-443-8;NSC 29844;UNII-T89I34ODAA;Telepathine (hydrochloride);T89I34ODAA;NSC-29844;7-Methoxy-1-methyl-9H-pyrido(3,4-b)indole hydrochloride;7-Methoxy-1-methyl-9H-pyrido-[3,4-b]indole hydrochloride;7-methoxy-1-methyl-9H-pyrido[3,4-b]indole;hydrochloride;9H-Pyrido(3,4-b)indole, 7-methoxy-1-methyl-, monohydrochloride;HARMINE, HYDROCHLORIDE, DIHYDRATE;MLS002153910;HarmineHydrochloride;SMR001233259;Prestwick_254;Harmine-hydrochloride;HARMINE?;Banisterine Hydrochloride;C13H12N2O.ClH;HARMINE, HYDROCHLORIDE;SCHEMBL1469013;CHEMBL1593867;DTXSID7052024;VNPLYCKZIUTKJM-UHFFFAOYSA-N;HMS1569L08;HY-N0737;NSC29844;MFCD00012641;AKOS015844691;CCG-208113;FS-5036;Harmine hydrochloride, >=98% (HPLC);NCGC00016435-08;AC-34980;LS-74062;CS-0009747;FT-0626861;H0002;S3817;WLN: T B656 EN HMJ F1 KO1 & GH;A14788;H-1250;A822169;Q-100415;SR-05000001527-6;9H-Pyrido[3, 7-methoxy-1-methyl-, monohydrochloride;Q27289808;7-METHOXY-1-METHYL-9H-PYRIDO(3,4-B)INDOLE MONOHYDROCHLORIDE;9H-PYRIDO(3,4-B)INDOLE, 7-METHOXY-1-METHYL-, HYDROCHLORIDE (1:1);9H-Pyrido(3,4-b)indole, 7-methoxy-1-methyl-, monohydrochloride (8CI,9CI)

Chemical Property of Harmine Hydrochloride

Chemical Property:

• Appearance/Colour: yellow to slightly green crystalline powder
• Vapor Pressure: 6.42E-07mmHg at 25°C
• Melting Point: 265-270 °C
• Boiling Point: 421.4 °C at 760 mmHg
• Flash Point: 139.8 °C
• PSA: 37.91000
• LogP: 3.83510
• Storage Temp.: 2-8°C
• Solubility.: Soluble in Water (up to 25 mg/ml).
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 248.0716407
• Heavy Atom Count: 17
• Complexity: 258

Purity/Quality:

99%, ^*data from raw suppliers

Harmine Hydrochloride >98.0%(HPLC)(T) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22-40
• Safety Statements: 22-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC=CC2=C1NC3=C2C=CC(=C3)OC.Cl
• Recent ClinicalTrials: Study of Harmine in Healthy Subjects
• Description: Harmine (343-27-1) is a selective competitive and reversible inhibitor of MAO-A (IC50?= 8 μM).1?Harmine is a potent and specific inhibitor of both the kinase activity and autophosphorylation of tyrosine during translation DYRK1A (IC50‘s: DYRKA1A = 33 nM; DYRKA1B = 166 nM; DYRK2 = 1.9 μM; DYRK4 = 80 μM).2,3?Inhibits self-renewal and promotes differentiation of glioblastoma stem-like cells (GSLC’s) possibly via inhibition of Akt phosphorylation.4?Harmine has also been shown to possess antimicrobial, antifungal, antiplasmodial, antitumor, antioxidant, antimutagenic and antigenotoxic properties.5?Inhibits osteoclast differentiation and bone resorption via downregulation of c-Fos and NFATc1 induced by RANKL.6
• Uses: Harmine Monohydrochloride is an anti-viral agents for the treatment of EV71 infection. It inhibits enterovirus 71 replication by targeting NF-κB pathway.

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