(2S,1'R)-1-benzyl-2-{1'-(dibenzylamino)-2'-[(tert-butyldimethylsilanyl)oxy]ethyl}aziridine

Base Information

Chemical Name:(2S,1'R)-1-benzyl-2-{1'-(dibenzylamino)-2'-[(tert-butyldimethylsilanyl)oxy]ethyl}aziridine
CAS No.:591750-70-8
Molecular Formula:C₃₁H₄₂N₂OSi
Molecular Weight:486.773
Hs Code.:

Synonyms:(2S,1'R)-1-benzyl-2-{1'-(dibenzylamino)-2'-[(tert-butyldimethylsilanyl)oxy]ethyl}aziridine

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Chemical Property of (2S,1'R)-1-benzyl-2-{1'-(dibenzylamino)-2'-[(tert-butyldimethylsilanyl)oxy]ethyl}aziridine

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Technology Process of (2S,1'R)-1-benzyl-2-{1'-(dibenzylamino)-2'-[(tert-butyldimethylsilanyl)oxy]ethyl}aziridine

There total 3 articles about (2S,1'R)-1-benzyl-2-{1'-(dibenzylamino)-2'-[(tert-butyldimethylsilanyl)oxy]ethyl}aziridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: (2R)-(Z)-N,N-dibenzyl-3-(benzylimino)-1-[(tert-butyldimethylsilanyl)oxy]-4-chlorobutan-2-amine

: 591750-70-8
(2S,1'R)-1-benzyl-2-{1'-(dibenzylamino)-2'-[(tert-butyldimethylsilanyl)oxy]ethyl}aziridine

Guidance literature:: (2R)-(Z)-N,N-dibenzyl-3-(benzylimino)-1-[(tert-butyldimethylsilanyl)oxy]-4-chlorobutan-2-amine; With sodium tetrahydroborate; In methanol; at -30 ℃; for 3h;

With methyllithium; In tetrahydrofuran; diethyl ether; at 0 - 20 ℃;
DOI:10.1021/jo0490806

Reference yield:

: 100-46-9
benzylamine

: 591750-70-8
(2S,1'R)-1-benzyl-2-{1'-(dibenzylamino)-2'-[(tert-butyldimethylsilanyl)oxy]ethyl}aziridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 93 percent / TiCl₄ / hexane; diethyl ether / 2 h / 20 °C

2.1: NaBH₄ / methanol / 3 h / -30 °C

2.2: 77 percent / MeLi / tetrahydrofuran; diethyl ether / 0 - 20 °C

With sodium tetrahydroborate; titanium tetrachloride; In methanol; diethyl ether; hexane;
DOI:10.1021/jo0490806

Reference yield:

: 388632-20-0
(-)-(3S)-3-(dibenzylamino)-4-[(tert-butyldimethylsilanyl)oxy]-1-chlorobutan-2-one

: 591750-70-8
(2S,1'R)-1-benzyl-2-{1'-(dibenzylamino)-2'-[(tert-butyldimethylsilanyl)oxy]ethyl}aziridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 93 percent / TiCl₄ / hexane; diethyl ether / 2 h / 20 °C

2.1: NaBH₄ / methanol / 3 h / -30 °C

2.2: 77 percent / MeLi / tetrahydrofuran; diethyl ether / 0 - 20 °C

With sodium tetrahydroborate; titanium tetrachloride; In methanol; diethyl ether; hexane;
DOI:10.1021/jo0490806