(2R,3S,4R)-N-benzyl-2-[(benzylamino)methyl]-3,4-isopropylidenedioxy-pyrrolidine

Base Information

• Chemical Name: (2R,3S,4R)-N-benzyl-2-[(benzylamino)methyl]-3,4-isopropylidenedioxy-pyrrolidine
• CAS No.: 924890-28-8
• Molecular Formula: C₂₂H₂₈N₂O₂
• Molecular Weight: 352.477
• Mol file: 924890-28-8.mol

Synonyms:(2R,3S,4R)-N-benzyl-2-[(benzylamino)methyl]-3,4-isopropylidenedioxy-pyrrolidine

Chemical Property of (2R,3S,4R)-N-benzyl-2-[(benzylamino)methyl]-3,4-isopropylidenedioxy-pyrrolidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of (2R,3S,4R)-N-benzyl-2-[(benzylamino)methyl]-3,4-isopropylidenedioxy-pyrrolidine

There total 1 articles about (2R,3S,4R)-N-benzyl-2-[(benzylamino)methyl]-3,4-isopropylidenedioxy-pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

Toluene-4-sulfonic acid (4R,5R)-5-((2R,3R)-3-benzenesulfonyl-oxiranyl)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester + benzylamine (100-46-9) → (2R,3S,4R)-N-benzyl-2-[(benzylamino)methyl]-3,4-isopropylidenedioxy-pyrrolidine (924890-28-8)

Guidance literature:

Toluene-4-sulfonic acid (4R,5R)-5-((2R,3R)-3-benzenesulfonyl-oxiranyl)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester; benzylamine; In methanol; for 12h; Heating;

With sodium tetrahydroborate; In methanol; at 0 ℃; for 0.5h;

DOI:10.1016/j.tet.2006.10.083

Reference yield: 60.0%

(2R,3S,4R)-N-benzyl-2-[(benzylamino)methyl]-3,4-isopropylidenedioxy-pyrrolidine (924890-28-8) + trifluoromethylsulfonic anhydride (358-23-6) → (2R,3S,4R)-N-benzyl-2-[(benzyl-trifluoromethanesulfonylamino)methyl]-3,4-isopropylidenedioxy-pyrrolidine

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.tet.2006.10.083

upstream raw materials:

benzylamine