(2R)-(1S,2R,4R)-10-dicyclohexylsulfamoylisobornyl 2-amino-2-aminomethyl-3-methylbutanoate

Base Information

Chemical Name:(2R)-(1S,2R,4R)-10-dicyclohexylsulfamoylisobornyl 2-amino-2-aminomethyl-3-methylbutanoate
CAS No.:173914-48-2
Molecular Formula:C₂₈H₅₁N₃O₄S
Molecular Weight:525.797
Hs Code.:

Synonyms:(2R)-(1S,2R,4R)-10-dicyclohexylsulfamoylisobornyl 2-amino-2-aminomethyl-3-methylbutanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R)-(1S,2R,4R)-10-dicyclohexylsulfamoylisobornyl 2-amino-2-aminomethyl-3-methylbutanoate

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Technology Process of (2R)-(1S,2R,4R)-10-dicyclohexylsulfamoylisobornyl 2-amino-2-aminomethyl-3-methylbutanoate

There total 4 articles about (2R)-(1S,2R,4R)-10-dicyclohexylsulfamoylisobornyl 2-amino-2-aminomethyl-3-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 173914-44-8
(2R)-(1S,2R,4R)-10-dicyclohexylsulfamoylisobornyl 2-amino-2-cyano-3-methylbutanoate

: 173914-48-2
(2R)-(1S,2R,4R)-10-dicyclohexylsulfamoylisobornyl 2-amino-2-aminomethyl-3-methylbutanoate

Guidance literature:: With ammonia; hydrogen; Rh/Al₂O₃; In ethanol; at 25 ℃; for 16h; under 760 Torr;
DOI:10.1016/0957-4166(95)00368-Y

Reference yield:

: 98134-33-9
2-Cyano-3-methylbutanoyl chloride

: 173914-48-2
(2R)-(1S,2R,4R)-10-dicyclohexylsulfamoylisobornyl 2-amino-2-aminomethyl-3-methylbutanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / AgCN / toluene / 80 °C

2: 1.) lithium hexamethyldisylylamide, 2.) O-(diphenylphosphinyl)hydroxylamine / 1.) THF, hexane, -78 deg C, 1 h, 2.) THF, hexane, RT, 12 h

3: 100 percent / H₂, NH₃ / Rh/Al₂O₃ / ethanol / 16 h / 25 °C / 760 Torr

With silver cyanide; O-(diphenylphosphinyl)hydroxylamine; ammonia; hydrogen; lithium hexamethyldisilazane; Rh/Al₂O₃; In ethanol; toluene;
DOI:10.1016/0957-4166(95)00368-Y

Reference yield:

: 96303-88-7
(-)-10-dicyclohexylsulfamoyl-D-isoborneol

: 173914-48-2
(2R)-(1S,2R,4R)-10-dicyclohexylsulfamoylisobornyl 2-amino-2-aminomethyl-3-methylbutanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / AgCN / toluene / 80 °C

2: 1.) lithium hexamethyldisylylamide, 2.) O-(diphenylphosphinyl)hydroxylamine / 1.) THF, hexane, -78 deg C, 1 h, 2.) THF, hexane, RT, 12 h

3: 100 percent / H₂, NH₃ / Rh/Al₂O₃ / ethanol / 16 h / 25 °C / 760 Torr

With silver cyanide; O-(diphenylphosphinyl)hydroxylamine; ammonia; hydrogen; lithium hexamethyldisilazane; Rh/Al₂O₃; In ethanol; toluene;
DOI:10.1016/0957-4166(95)00368-Y