5-{[(1R,2S)-2-aminocyclohexyl]amino}-3-({5-[3-(2,2-difluoro-1-hydroxyethyl)phenyl]-6-methylpyridin-2-yl}amino)pyridine-2-carboxamide

Base Information

Chemical Name:5-{[(1R,2S)-2-aminocyclohexyl]amino}-3-({5-[3-(2,2-difluoro-1-hydroxyethyl)phenyl]-6-methylpyridin-2-yl}amino)pyridine-2-carboxamide
CAS No.:1429911-62-5
Molecular Formula:C₂₆H₃₀F₂N₆O₂
Molecular Weight:496.56
Hs Code.:

Synonyms:5-{[(1R,2S)-2-aminocyclohexyl]amino}-3-({5-[3-(2,2-difluoro-1-hydroxyethyl)phenyl]-6-methylpyridin-2-yl}amino)pyridine-2-carboxamide

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Chemical Property of 5-{[(1R,2S)-2-aminocyclohexyl]amino}-3-({5-[3-(2,2-difluoro-1-hydroxyethyl)phenyl]-6-methylpyridin-2-yl}amino)pyridine-2-carboxamide

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Technology Process of 5-{[(1R,2S)-2-aminocyclohexyl]amino}-3-({5-[3-(2,2-difluoro-1-hydroxyethyl)phenyl]-6-methylpyridin-2-yl}amino)pyridine-2-carboxamide

There total 7 articles about 5-{[(1R,2S)-2-aminocyclohexyl]amino}-3-({5-[3-(2,2-difluoro-1-hydroxyethyl)phenyl]-6-methylpyridin-2-yl}amino)pyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₆H₂₈F₂N₆O

: 1429911-62-5
5-{[(1R,2S)-2-aminocyclohexyl]amino}-3-({5-[3-(2,2-difluoro-1-hydroxyethyl)phenyl]-6-methylpyridin-2-yl}amino)pyridine-2-carboxamide

Guidance literature:: With dihydrogen peroxide; sodium hydroxide; In 1-methyl-pyrrolidin-2-one; water; at 20 ℃; for 3h;

Reference yield:

: 1429912-91-3
tert-butyl (1S,2R)-2-(5-(5-bromo-6-methylpyridin-2-ylamino)-6-cyanopyridin-3-ylamino)cyclohexylcarbamate

: 1429911-62-5
5-{[(1R,2S)-2-aminocyclohexyl]amino}-3-({5-[3-(2,2-difluoro-1-hydroxyethyl)phenyl]-6-methylpyridin-2-yl}amino)pyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; phosphate potassium salt / 1,4-dioxane / 16 h / 80 °C / Inert atmosphere

2: trifluoroacetic acid

3: dihydrogen peroxide; sodium hydroxide / 1-methyl-pyrrolidin-2-one; water / 3 h / 20 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; phosphate potassium salt; dihydrogen peroxide; trifluoroacetic acid; sodium hydroxide; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; water;

Reference yield:

: 365996-30-1
tert-butyl ((1S,2R)-2-aminocyclohexyl)carbamate

: 1429911-62-5
5-{[(1R,2S)-2-aminocyclohexyl]amino}-3-({5-[3-(2,2-difluoro-1-hydroxyethyl)phenyl]-6-methylpyridin-2-yl}amino)pyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 24 h / 120 °C / Sealed tube

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 4.5 h / 85 °C / Inert atmosphere

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; phosphate potassium salt / 1,4-dioxane / 16 h / 80 °C / Inert atmosphere

4: trifluoroacetic acid

5: dihydrogen peroxide; sodium hydroxide / 1-methyl-pyrrolidin-2-one; water / 3 h / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; phosphate potassium salt; dihydrogen peroxide; caesium carbonate; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; sodium hydroxide; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; water;