methyl {4-[2-(1-{4-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-2-oxo-1(2H)-pyridinyl}-3-methoxypropyl)-1H-imidazol-5-yl]phenyl}carbamate

Base Information

Chemical Name:methyl {4-[2-(1-{4-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-2-oxo-1(2H)-pyridinyl}-3-methoxypropyl)-1H-imidazol-5-yl]phenyl}carbamate
CAS No.:1445954-39-1
Molecular Formula:C₂₇H₂₅ClN₈O₄
Molecular Weight:561
Hs Code.:

Synonyms:methyl {4-[2-(1-{4-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-2-oxo-1(2H)-pyridinyl}-3-methoxypropyl)-1H-imidazol-5-yl]phenyl}carbamate

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Chemical Property of methyl {4-[2-(1-{4-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-2-oxo-1(2H)-pyridinyl}-3-methoxypropyl)-1H-imidazol-5-yl]phenyl}carbamate

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Technology Process of methyl {4-[2-(1-{4-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-2-oxo-1(2H)-pyridinyl}-3-methoxypropyl)-1H-imidazol-5-yl]phenyl}carbamate

There total 8 articles about methyl {4-[2-(1-{4-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-2-oxo-1(2H)-pyridinyl}-3-methoxypropyl)-1H-imidazol-5-yl]phenyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₇H₂₅ClN₆O₇

: 1445954-39-1
methyl {4-[2-(1-{4-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-2-oxo-1(2H)-pyridinyl}-3-methoxypropyl)-1H-imidazol-5-yl]phenyl}carbamate

Guidance literature:: With ammonium acetate; In toluene; for 12h; Reflux;

Reference yield:

: 219954-11-7
tert-butyl 2-[4-(benzyloxy)-2-oxo-1,2-dihydropyridin-1-yl]acetate

: 1445954-39-1
methyl {4-[2-(1-{4-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-2-oxo-1(2H)-pyridinyl}-3-methoxypropyl)-1H-imidazol-5-yl]phenyl}carbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.5 h / -78 °C

2.1: 5%-palladium/activated carbon; hydrogen / ethanol / 4 h

3.1: triethylamine / N,N-dimethyl-formamide / 1 h / 20 °C

4.1: cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.5 h / 105 °C / Inert atmosphere

5.1: acetic acid / 0.5 h

5.2: 16 h / 20 °C

6.1: hydrogenchloride / water; 1,4-dioxane / 3 h / 90 °C

7.1: potassium carbonate / acetonitrile / 8 h / 50 °C

8.1: ammonium acetate / toluene / 12 h / Reflux

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 5%-palladium/activated carbon; ammonium acetate; hydrogen; potassium carbonate; acetic acid; triethylamine; cesium fluoride; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: C₁₄H₂₁NO₅

: 1445954-39-1
methyl {4-[2-(1-{4-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-2-oxo-1(2H)-pyridinyl}-3-methoxypropyl)-1H-imidazol-5-yl]phenyl}carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / N,N-dimethyl-formamide / 1 h / 20 °C

2.1: cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.5 h / 105 °C / Inert atmosphere

3.1: acetic acid / 0.5 h

3.2: 16 h / 20 °C

4.1: hydrogenchloride / water; 1,4-dioxane / 3 h / 90 °C

5.1: potassium carbonate / acetonitrile / 8 h / 50 °C

6.1: ammonium acetate / toluene / 12 h / Reflux

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonium acetate; potassium carbonate; acetic acid; triethylamine; cesium fluoride; In 1,4-dioxane; water; N,N-dimethyl-formamide; toluene; acetonitrile;