5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)-1-[2-(trifluoromethyl)benzyl]pyridazin-4(1H)-one

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Chemical Name:5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)-1-[2-(trifluoromethyl)benzyl]pyridazin-4(1H)-one
CAS No.:1357591-80-0
Molecular Formula:C₂₂H₁₇F₃N₄O₂
Molecular Weight:426.398
Hs Code.:

Synonyms:5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)-1-[2-(trifluoromethyl)benzyl]pyridazin-4(1H)-one

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Chemical Property of 5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)-1-[2-(trifluoromethyl)benzyl]pyridazin-4(1H)-one

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Technology Process of 5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)-1-[2-(trifluoromethyl)benzyl]pyridazin-4(1H)-one

There total 8 articles about 5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)-1-[2-(trifluoromethyl)benzyl]pyridazin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 395-44-8
o-trifluoromethylbenzyl bromide

: 1357192-32-5
5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4-ol

: 1357591-80-0
5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)-1-[2-(trifluoromethyl)benzyl]pyridazin-4(1H)-one

Guidance literature:: 5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4-ol; With tetra-(n-butyl)ammonium iodide; sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.333333h;

o-trifluoromethylbenzyl bromide; In N,N-dimethyl-formamide; at 20 ℃; for 60h;

Reference yield:

: 1238702-56-1
(1-phenyl-1H-pyrazol-5-yl)boronic acid

: 1357591-80-0
5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)-1-[2-(trifluoromethyl)benzyl]pyridazin-4(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene / 48 h / 20 - 40 °C

2.1: bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); potassium carbonate / water; toluene / 24 °C / Reflux; Inert atmosphere

3.1: 10 wt% Pd(OH)2 on carbon; hydrogen / methanol; tetrahydrofuran / 48 h / 20 °C

4.1: sodium hydride; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C

4.2: 60 h / 20 °C

With bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); 10 wt% Pd(OH)2 on carbon; hydrogen; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 1126-00-7
1-phenylpyrazole

: 1357591-80-0
5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)-1-[2-(trifluoromethyl)benzyl]pyridazin-4(1H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

1.2: 21 h / -78 - 20 °C

2.1: toluene / 48 h / 20 - 40 °C

3.1: bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); potassium carbonate / water; toluene / 24 °C / Reflux; Inert atmosphere

4.1: 10 wt% Pd(OH)2 on carbon; hydrogen / methanol; tetrahydrofuran / 48 h / 20 °C

5.1: sodium hydride; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C

5.2: 60 h / 20 °C

With n-butyllithium; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); 10 wt% Pd(OH)2 on carbon; hydrogen; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene; mineral oil;