methyl 4-[4-(4-cyanophenyl)-2-formylbutyl]benzoate

Base Information

• Chemical Name: methyl 4-[4-(4-cyanophenyl)-2-formylbutyl]benzoate
• CAS No.: 934737-83-4
• Molecular Formula: C₂₀H₁₉NO₃
• Molecular Weight: 321.376
• Mol file: 934737-83-4.mol

Synonyms:methyl 4-[4-(4-cyanophenyl)-2-formylbutyl]benzoate

Chemical Property of methyl 4-[4-(4-cyanophenyl)-2-formylbutyl]benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-[4-(4-cyanophenyl)-2-formylbutyl]benzoate

There total 10 articles about methyl 4-[4-(4-cyanophenyl)-2-formylbutyl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

methyl 4-[4-(4-cyanophenyl)-2-hydroxymethylbutyl]benzoate (934737-82-3) → methyl 4-[4-(4-cyanophenyl)-2-formylbutyl]benzoate (934737-83-4)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; at 20 ℃; for 5h;

Reference yield:

1-(2-bromoethyl)-4-hydroxymethylbenzene → methyl 4-[4-(4-cyanophenyl)-2-formylbutyl]benzoate (934737-83-4)

Guidance literature:

Multi-step reaction with 6 steps

1.1: pyridinium chlorochromate / dichloromethane / 20 °C

2.1: formic acid; hydroxylamine hydrochloride / 2 h / Reflux

3.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

3.2: 0 - 20 °C

4.1: formic acid; triethylamine; triphenylphosphine / palladium diacetate / 1,4-dioxane / 20 - 100 °C

5.1: borane-THF / tetrahydrofuran / -15 °C

6.1: pyridinium chlorochromate / dichloromethane / 5 h / 20 °C

With formic acid; borane-THF; hydroxylamine hydrochloride; sodium hydride; triethylamine; triphenylphosphine; pyridinium chlorochromate; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

4-(2-bromoethyl)benzonitrile (72054-56-9) → methyl 4-[4-(4-cyanophenyl)-2-formylbutyl]benzoate (934737-83-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

1.2: 0 - 20 °C

2.1: formic acid; triethylamine; triphenylphosphine / palladium diacetate / 1,4-dioxane / 20 - 100 °C

3.1: borane-THF / tetrahydrofuran / -15 °C

4.1: pyridinium chlorochromate / dichloromethane / 5 h / 20 °C

With formic acid; borane-THF; sodium hydride; triethylamine; triphenylphosphine; pyridinium chlorochromate; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

methyl 4-[4-(4-cyanophenyl)-2-hydroxymethylbutyl]benzoate

4-(2-bromoethyl)benzonitrile

diallyl 2-(4-methoxycarbonylbenzyl)malonate

methyl 4-[2-carboxy-4-(4-cyanophenyl)butyl]benzoate

Downstream raw materials:

methyl (E)-4-[2-[2-(4-cyanophenyl)ethyl]-4-(2-hydroxyphenyl)but-3-enyl]benzoate

Methyl 4-{(3E)-4-{2-[(2-chlorobenzyl)oxy]phenyl}-2-[2-(4-cyanophenyl)ethyl]but-3-en-1-yl}-benzoate

Methyl 4-{(3E)-4-{2-[(4-tert-butylbenzyl)oxy]phenyl}-2-[2-(4-cyanophenyl)ethyl]but-3-en-1-yl}-benzoate

4-((3E)-4-{2-[(2-chlorobenzyl)oxy]phenyl}-2-{2-[4-(1H-tetrazol-5-yl)phenyl]ethyl}but-3-en-1-yl)benzoic acid