(S)-1-(4-fluorobenzyl)-5-(2-(4-fluorophenoxymethyl)-pyrrolidine-1-sulfonyl)isatin

Base Information

Chemical Name:(S)-1-(4-fluorobenzyl)-5-(2-(4-fluorophenoxymethyl)-pyrrolidine-1-sulfonyl)isatin
CAS No.:1092522-60-5
Molecular Formula:C₂₆H₂₂F₂N₂O₅S
Molecular Weight:512.534
Hs Code.:

Synonyms:(S)-1-(4-fluorobenzyl)-5-(2-(4-fluorophenoxymethyl)-pyrrolidine-1-sulfonyl)isatin

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Chemical Property of (S)-1-(4-fluorobenzyl)-5-(2-(4-fluorophenoxymethyl)-pyrrolidine-1-sulfonyl)isatin

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Technology Process of (S)-1-(4-fluorobenzyl)-5-(2-(4-fluorophenoxymethyl)-pyrrolidine-1-sulfonyl)isatin

There total 5 articles about (S)-1-(4-fluorobenzyl)-5-(2-(4-fluorophenoxymethyl)-pyrrolidine-1-sulfonyl)isatin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1092522-53-6
(S)-5-(2-(4-fluorophenoxymethyl)-pyrrolidine-1-sulfonyl)isatin

: 459-46-1
4-Fluorobenzyl bromide

: 1092522-60-5
(S)-1-(4-fluorobenzyl)-5-(2-(4-fluorophenoxymethyl)-pyrrolidine-1-sulfonyl)isatin

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm801107u

Reference yield:

: 132898-96-5
5-chlorosulfonylisatin

: 1092522-60-5
(S)-1-(4-fluorobenzyl)-5-(2-(4-fluorophenoxymethyl)-pyrrolidine-1-sulfonyl)isatin

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; trifluoroacetic acid / tetrahydrofuran; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran

2: potassium carbonate / N,N-dimethyl-formamide; diethyl ether

With potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; N,N-dimethyl-formamide;

Reference yield:

: (S)-tert-Butyl 2-(4-fluorophenoxymethyl)pyrrolidine-1-carboxylate

: 1092522-60-5
(S)-1-(4-fluorobenzyl)-5-(2-(4-fluorophenoxymethyl)-pyrrolidine-1-sulfonyl)isatin

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; trifluoroacetic acid / tetrahydrofuran; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran

2: potassium carbonate / N,N-dimethyl-formamide; diethyl ether

With potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; N,N-dimethyl-formamide;