2-((2,6-difluorobenzyl)thio)-5-(pyrazin-2-yl)-1,3,4-thiadiazole

Base Information

• Chemical Name: 2-((2,6-difluorobenzyl)thio)-5-(pyrazin-2-yl)-1,3,4-thiadiazole
• CAS No.: 1404052-60-3
• Molecular Formula: C₁₃H₈F₂N₄S₂
• Molecular Weight: 322.362
• Mol file: 1404052-60-3.mol

Synonyms:2-((2,6-difluorobenzyl)thio)-5-(pyrazin-2-yl)-1,3,4-thiadiazole

Chemical Property of 2-((2,6-difluorobenzyl)thio)-5-(pyrazin-2-yl)-1,3,4-thiadiazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-((2,6-difluorobenzyl)thio)-5-(pyrazin-2-yl)-1,3,4-thiadiazole

There total 4 articles about 2-((2,6-difluorobenzyl)thio)-5-(pyrazin-2-yl)-1,3,4-thiadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

2,6-Difluorobenzyl bromide (85118-00-9) + 5-(2-pyrazinyl)-1,3,4-thiadiazole-2-thiol (37545-34-9) → 2-((2,6-difluorobenzyl)thio)-5-(pyrazin-2-yl)-1,3,4-thiadiazole (1404052-60-3)

Guidance literature:

With potassium carbonate; In acetone; Reflux;

DOI:10.1016/j.bmc.2012.08.059

Reference yield:

potassium 2-(pyrazine-2-carbonyl)hydrazinecarbodithioate (37545-37-2) → 2-((2,6-difluorobenzyl)thio)-5-(pyrazin-2-yl)-1,3,4-thiadiazole (1404052-60-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / 0 °C

2: potassium carbonate / acetone / Reflux

With sulfuric acid; potassium carbonate; In acetone;

DOI:10.1016/j.bmc.2012.08.059

Reference yield:

pyrazine-2-carbohydrazide (768-05-8) → 2-((2,6-difluorobenzyl)thio)-5-(pyrazin-2-yl)-1,3,4-thiadiazole (1404052-60-3)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium hydroxide / methanol / 20 °C

2: sulfuric acid / 0 °C

3: potassium carbonate / acetone / Reflux

With sulfuric acid; potassium carbonate; potassium hydroxide; In methanol; acetone;

DOI:10.1016/j.bmc.2012.08.059

upstream raw materials:

2,6-Difluorobenzyl bromide

5-(2-pyrazinyl)-1,3,4-thiadiazole-2-thiol

potassium 2-(pyrazine-2-carbonyl)hydrazinecarbodithioate

pyrazine-2-carbohydrazide