benzyl [(2S)-1-{[(2S)-4,4-difluoro-3-oxo-1,6-diphenylhexan-2-yl]amino}-3-methyl-1-oxobutan-2-yl]carbamate

Base Information

Chemical Name:benzyl [(2S)-1-{[(2S)-4,4-difluoro-3-oxo-1,6-diphenylhexan-2-yl]amino}-3-methyl-1-oxobutan-2-yl]carbamate
CAS No.:134450-34-3
Molecular Formula:C31H34F2N2O4
Molecular Weight:536.6095
Hs Code.:
Mol file:134450-34-3.mol

Synonyms:

Suppliers and Price of benzyl [(2S)-1-{[(2S)-4,4-difluoro-3-oxo-1,6-diphenylhexan-2-yl]amino}-3-methyl-1-oxobutan-2-yl]carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of benzyl [(2S)-1-{[(2S)-4,4-difluoro-3-oxo-1,6-diphenylhexan-2-yl]amino}-3-methyl-1-oxobutan-2-yl]carbamate

Chemical Property:

Vapor Pressure:3.9E-20mmHg at 25°C
Boiling Point:712.3°C at 760 mmHg
Flash Point:384.6°C
Density:1.185g/cm³

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of benzyl [(2S)-1-{[(2S)-4,4-difluoro-3-oxo-1,6-diphenylhexan-2-yl]amino}-3-methyl-1-oxobutan-2-yl]carbamate

There total 10 articles about benzyl [(2S)-1-{[(2S)-4,4-difluoro-3-oxo-1,6-diphenylhexan-2-yl]amino}-3-methyl-1-oxobutan-2-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 72155-45-4
Boc-L-phenylalaninal

: 134450-34-3
2S-(N-Benzyloxycarbonyl-valinyl)amino-3-oxo-4,4-difluoro-1,6-diphenyl-hexane

Guidance literature:: Multi-step reaction with 5 steps

1: 32 percent / Zn dust, HgCl₂ / tetrahydrofuran / 0.5 h / Ambient temperature; sonification

2: 96 percent / H₂ / 10percent Pd/C / ethanol / 1 h

3: CF₃COOH / CH₂Cl₂ / 0.5 h / Ambient temperature

4: 88 percent / DCC, HOBt

5: Na₂Cr₂O₇ / acetic acid

With sodium dichromate; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; mercury dichloride; zinc; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; acetic acid;
DOI:10.1016/0022-1139(94)03223-M

Reference yield:

: 66605-57-0
(S)-N-tert-butoxycarbonyl-2-amino-3-phenylpropanol

: 134450-34-3
2S-(N-Benzyloxycarbonyl-valinyl)amino-3-oxo-4,4-difluoro-1,6-diphenyl-hexane

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) DMSO, oxalyl chloride, 2.) NEt₃ / 1.) CH₂Cl₂, -78 deg C, 15 min, 2.) -78 deg C, 25 min

2: 32 percent / Zn dust, HgCl₂ / tetrahydrofuran / 0.5 h / Ambient temperature; sonification

3: 96 percent / H₂ / 10percent Pd/C / ethanol / 1 h

4: CF₃COOH / CH₂Cl₂ / 0.5 h / Ambient temperature

5: 88 percent / DCC, HOBt

6: Na₂Cr₂O₇ / acetic acid

With sodium dichromate; oxalyl dichloride; hydrogen; benzotriazol-1-ol; dimethyl sulfoxide; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; mercury dichloride; zinc; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; acetic acid;
DOI:10.1016/0022-1139(94)03223-M

Reference yield:

: 147770-25-0
((1S,2R)-1-Benzyl-3,3-difluoro-2-hydroxy-5-phenyl-pent-4-ynyl)-carbamic acid tert-butyl ester

: 134450-34-3
2S-(N-Benzyloxycarbonyl-valinyl)amino-3-oxo-4,4-difluoro-1,6-diphenyl-hexane

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / H₂ / 10percent Pd/C / ethanol / 1 h

2: CF₃COOH / CH₂Cl₂ / 0.5 h / Ambient temperature

3: 88 percent / DCC, HOBt

4: Na₂Cr₂O₇ / acetic acid

With sodium dichromate; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In ethanol; dichloromethane; acetic acid;
DOI:10.1016/0022-1139(94)03223-M