methyl 4-[2-chloro-5-(2,3-difluoro-6-methoxy-benzyloxy)-4-methoxyphenylamino]-2-cyanopyrimidine-5-carboxylate

Base Information

Chemical Name:methyl 4-[2-chloro-5-(2,3-difluoro-6-methoxy-benzyloxy)-4-methoxyphenylamino]-2-cyanopyrimidine-5-carboxylate
CAS No.:1073438-03-5
Molecular Formula:C₂₂H₁₇ClF₂N₄O₅
Molecular Weight:490.851
Hs Code.:

Synonyms:methyl 4-[2-chloro-5-(2,3-difluoro-6-methoxy-benzyloxy)-4-methoxyphenylamino]-2-cyanopyrimidine-5-carboxylate

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Chemical Property of methyl 4-[2-chloro-5-(2,3-difluoro-6-methoxy-benzyloxy)-4-methoxyphenylamino]-2-cyanopyrimidine-5-carboxylate

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Technology Process of methyl 4-[2-chloro-5-(2,3-difluoro-6-methoxy-benzyloxy)-4-methoxyphenylamino]-2-cyanopyrimidine-5-carboxylate

There total 1 articles about methyl 4-[2-chloro-5-(2,3-difluoro-6-methoxy-benzyloxy)-4-methoxyphenylamino]-2-cyanopyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: potassium cyanide

: 1073438-02-4
methyl 2-chloro-4-[2-chloro-5-(2,3-difluoro-6-methoxybenzyloxy)-4-methoxyphenylamino]-pyrimidine-5-carboxylate

: 1073438-03-5
methyl 4-[2-chloro-5-(2,3-difluoro-6-methoxy-benzyloxy)-4-methoxyphenylamino]-2-cyanopyrimidine-5-carboxylate

Guidance literature:: With 1,4-diaza-bicyclo[2.2.2]octane; In water; dimethyl sulfoxide; at 30 ℃; for 10h;

Reference yield:

: 1073438-03-5
methyl 4-[2-chloro-5-(2,3-difluoro-6-methoxy-benzyloxy)-4-methoxyphenylamino]-2-cyanopyrimidine-5-carboxylate

: 1073438-04-6
4-[2-chloro-5-(2,3-difluoro-6-methoxybenzyloxy)-4-methoxyphenylamino]-2-cyanopyrimidine-5-carboxylic acid

Guidance literature:: methyl 4-[2-chloro-5-(2,3-difluoro-6-methoxy-benzyloxy)-4-methoxyphenylamino]-2-cyanopyrimidine-5-carboxylate; With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 20 ℃; for 1h;

With hydrogenchloride; In tetrahydrofuran; water;