anti-2,4-pentadiynal tosylhydrazone

Base Information

• Chemical Name: anti-2,4-pentadiynal tosylhydrazone
• CAS No.: 882044-94-2
• Molecular Formula: C₁₂H₁₀N₂O₂S
• Molecular Weight: 246.29
• Mol file: 882044-94-2.mol

Synonyms:anti-2,4-pentadiynal tosylhydrazone

Chemical Property of anti-2,4-pentadiynal tosylhydrazone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of anti-2,4-pentadiynal tosylhydrazone

There total 4 articles about anti-2,4-pentadiynal tosylhydrazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

1,1-diethoxy-2,4-pentadiyne (3777-61-5) + toluene-4-sulfonic acid hydrazide (1576-35-8) → 1-tosyl-5-ethynylpyrazole + syn-2,4-pentadiynal tosylhydrazone + anti-2,4-pentadiynal tosylhydrazone (882044-94-2)

Guidance literature:

With 4-methylmorpholine N-oxide; triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1021/jo0622025

Reference yield:

2,4-pentadiyne-1-ol (41345-53-3) → anti-2,4-pentadiynal tosylhydrazone (882044-94-2)

Guidance literature:

Multi-step reaction with 2 steps

1: Dess-Martin periodinane / CH₂Cl₂ / 1.5 h / 25 °C

2: 0.95 g / diethyl ether / 24 h / 25 °C

With Dess-Martin periodane; In diethyl ether; dichloromethane;

DOI:10.1021/ja058252t

Reference yield:

(Z)-1-chloro-5,5-diethoxyprop-1-en-3-yne (114534-23-5) → anti-2,4-pentadiynal tosylhydrazone (882044-94-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 33 percent / n-Bu₄NF / tetrahydrofuran / 19 h / 20 °C

2: H₂SO₄ / ethanol; H₂O / 3 h / 45 °C

With sulfuric acid; tetrabutyl ammonium fluoride; In tetrahydrofuran; ethanol; water;

DOI:10.1021/ja058252t

upstream raw materials:

1,1-diethoxy-2,4-pentadiyne

toluene-4-sulfonic acid hydrazide

2,4-pentadiynal

2,4-pentadiyne-1-ol