(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(4-((N-(2-morpholinoethyl)methylsulfonamido)methyl)benzoyloxy)ethyl)pyridine 1-oxide

Base Information

Chemical Name:(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(4-((N-(2-morpholinoethyl)methylsulfonamido)methyl)benzoyloxy)ethyl)pyridine 1-oxide
CAS No.:1610861-13-6
Molecular Formula:C₃₃H₃₇Cl₂F₂N₃O₈S
Molecular Weight:744.641
Hs Code.:

(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(4-((N-(2-morpholinoethyl)methylsulfonamido)methyl)benzoyloxy)ethyl)pyridine 1-oxide

Synonyms:(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(4-((N-(2-morpholinoethyl)methylsulfonamido)methyl)benzoyloxy)ethyl)pyridine 1-oxide

Suppliers and Price of (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(4-((N-(2-morpholinoethyl)methylsulfonamido)methyl)benzoyloxy)ethyl)pyridine 1-oxide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(4-((N-(2-morpholinoethyl)methylsulfonamido)methyl)benzoyloxy)ethyl)pyridine 1-oxide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(4-((N-(2-morpholinoethyl)methylsulfonamido)methyl)benzoyloxy)ethyl)pyridine 1-oxide

There total 4 articles about (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(4-((N-(2-morpholinoethyl)methylsulfonamido)methyl)benzoyloxy)ethyl)pyridine 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-hydroxyethyl)pyridine 1-oxide

: 1610861-14-7
4-(2-(N-(4-carboxybenzyl)methylsulfonamido)ethyl)morpholin-4-ium chloride

: 1610861-13-6
(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(4-((N-(2-morpholinoethyl)methylsulfonamido)methyl)benzoyloxy)ethyl)pyridine 1-oxide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 6232-11-7
methyl 4-(aminomethyl)benzoate hydrochloride

: 1610861-13-6
(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(4-((N-(2-morpholinoethyl)methylsulfonamido)methyl)benzoyloxy)ethyl)pyridine 1-oxide

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / 3 h / 20 °C

2: potassium carbonate / acetonitrile / 3 h / Reflux

3: hydrogenchloride / 1,4-dioxane; water / 3 h / 70 °C

4: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C

With pyridine; hydrogenchloride; dmap; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; dichloromethane; water; acetonitrile;

Reference yield:

: 152122-32-2
methyl 4-(methylsulfonamidomethyl)benzoate

: 1610861-13-6
(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(4-((N-(2-morpholinoethyl)methylsulfonamido)methyl)benzoyloxy)ethyl)pyridine 1-oxide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 3 h / Reflux

2: hydrogenchloride / 1,4-dioxane; water / 3 h / 70 °C

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 20 °C

With hydrogenchloride; dmap; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; dichloromethane; water; acetonitrile;