(R)-4-Oxo-6-{3-[(4R,5R)-2-((E)-pent-1-enyl)-4,5-diphenyl-[1,3]dioxolan-2-yl]-propyl}-2-pentyl-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

Base Information

Chemical Name:(R)-4-Oxo-6-{3-[(4R,5R)-2-((E)-pent-1-enyl)-4,5-diphenyl-[1,3]dioxolan-2-yl]-propyl}-2-pentyl-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester
CAS No.:219986-33-1
Molecular Formula:C₄₁H₄₉NO₅
Molecular Weight:635.844
Hs Code.:

Synonyms:(R)-4-Oxo-6-{3-[(4R,5R)-2-((E)-pent-1-enyl)-4,5-diphenyl-[1,3]dioxolan-2-yl]-propyl}-2-pentyl-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

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Chemical Property of (R)-4-Oxo-6-{3-[(4R,5R)-2-((E)-pent-1-enyl)-4,5-diphenyl-[1,3]dioxolan-2-yl]-propyl}-2-pentyl-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

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Technology Process of (R)-4-Oxo-6-{3-[(4R,5R)-2-((E)-pent-1-enyl)-4,5-diphenyl-[1,3]dioxolan-2-yl]-propyl}-2-pentyl-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

There total 13 articles about (R)-4-Oxo-6-{3-[(4R,5R)-2-((E)-pent-1-enyl)-4,5-diphenyl-[1,3]dioxolan-2-yl]-propyl}-2-pentyl-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 133445-00-8
(1R,2R)-1,2-diphenyl-1,2-ethanediol bis(trimethylsilyl) ether

: 219986-31-9
(R)-4-Oxo-6-((E)-4-oxo-non-5-enyl)-2-pentyl-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

: 219986-33-1
(R)-4-Oxo-6-{3-[(4R,5R)-2-((E)-pent-1-enyl)-4,5-diphenyl-[1,3]dioxolan-2-yl]-propyl}-2-pentyl-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate;
DOI:10.1039/a807448h

Reference yield:

: 6393-56-2
pentylmagnesium chloride

: 219986-33-1
(R)-4-Oxo-6-{3-[(4R,5R)-2-((E)-pent-1-enyl)-4,5-diphenyl-[1,3]dioxolan-2-yl]-propyl}-2-pentyl-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: 2.) H₃O(+) / 1.) TFH, toluene, -78 deg C

2: NaOMe / methanol

3: HCl, H₂O

4: 90 percent / n-BuLi

5: CuBr

6: Pd(OAc)2 / acetonitrile

7: oxalic acid

8: NIS, PPh₃

9: NaHMDS

10: 1.) LHMDS, 2.) HCl, H₂O / 1.) THF

11: 87 percent / TMSOTf

With hydrogenchloride; palladium diacetate; N-iodo-succinimide; n-butyllithium; trimethylsilyl trifluoromethanesulfonate; oxonium; water; sodium methylate; sodium hexamethyldisilazane; oxalic acid; triphenylphosphine; copper(I) bromide; lithium hexamethyldisilazane; In methanol; acetonitrile;
DOI:10.1039/a807448h

Reference yield:

: 126378-42-5
4-methoxy-3-(trisopropylsilyl)pyridine

: 219986-33-1
(R)-4-Oxo-6-{3-[(4R,5R)-2-((E)-pent-1-enyl)-4,5-diphenyl-[1,3]dioxolan-2-yl]-propyl}-2-pentyl-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 12 steps

2: 2.) H₃O(+) / 1.) TFH, toluene, -78 deg C

3: NaOMe / methanol

4: HCl, H₂O

5: 90 percent / n-BuLi

6: CuBr

7: Pd(OAc)2 / acetonitrile

8: oxalic acid

9: NIS, PPh₃

10: NaHMDS

11: 1.) LHMDS, 2.) HCl, H₂O / 1.) THF

12: 87 percent / TMSOTf

With hydrogenchloride; palladium diacetate; N-iodo-succinimide; n-butyllithium; trimethylsilyl trifluoromethanesulfonate; oxonium; water; sodium methylate; sodium hexamethyldisilazane; oxalic acid; triphenylphosphine; copper(I) bromide; lithium hexamethyldisilazane; In methanol; acetonitrile;
DOI:10.1039/a807448h