(3S,3aS,6aS)-2-Benzyl-3-((S)-1-benzyloxy-ethyl)-tetrahydro-furo[2,3-d]isoxazol-5-one

Base Information

Chemical Name:(3S,3aS,6aS)-2-Benzyl-3-((S)-1-benzyloxy-ethyl)-tetrahydro-furo[2,3-d]isoxazol-5-one
CAS No.:177981-88-3
Molecular Formula:C₂₁H₂₃NO₄
Molecular Weight:353.418
Hs Code.:

Synonyms:(3S,3aS,6aS)-2-Benzyl-3-((S)-1-benzyloxy-ethyl)-tetrahydro-furo[2,3-d]isoxazol-5-one

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Chemical Property of (3S,3aS,6aS)-2-Benzyl-3-((S)-1-benzyloxy-ethyl)-tetrahydro-furo[2,3-d]isoxazol-5-one

Chemical Property:

Purity/Quality:

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Technology Process of (3S,3aS,6aS)-2-Benzyl-3-((S)-1-benzyloxy-ethyl)-tetrahydro-furo[2,3-d]isoxazol-5-one

There total 3 articles about (3S,3aS,6aS)-2-Benzyl-3-((S)-1-benzyloxy-ethyl)-tetrahydro-furo[2,3-d]isoxazol-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 61550-02-5
(furan-2-yloxy)-trimethylsilane

: C₂₄H₃₁NO₄Si

: 177981-88-3
(3S,3aS,6aS)-2-Benzyl-3-((S)-1-benzyloxy-ethyl)-tetrahydro-furo[2,3-d]isoxazol-5-one

: (3R,3aS,6aS)-2-Benzyl-3-((S)-1-benzyloxy-ethyl)-tetrahydro-furo[2,3-d]isoxazol-5-one

: 178151-97-8
(3R,3aR,6aR)-2-Benzyl-3-((S)-1-benzyloxy-ethyl)-tetrahydro-furo[2,3-d]isoxazol-5-one

Guidance literature:: With (-)-diisopinocampheylborane triflate; In dichloromethane; at -78 - 20 ℃; for 4h; Yield given. Yields of byproduct given;
DOI:10.1016/0957-4166(96)00110-3

Reference yield:

: 61550-02-5
(furan-2-yloxy)-trimethylsilane

: 177981-87-2
(Z)-N-[(S)-benzoxypropylidene]benzylamine N-oxide

: 177981-88-3
(3S,3aS,6aS)-2-Benzyl-3-((S)-1-benzyloxy-ethyl)-tetrahydro-furo[2,3-d]isoxazol-5-one

: (3S,3aR,6aR)-2-Benzyl-3-((S)-1-benzyloxy-ethyl)-tetrahydro-furo[2,3-d]isoxazol-5-one

: (3R,3aS,6aS)-2-Benzyl-3-((S)-1-benzyloxy-ethyl)-tetrahydro-furo[2,3-d]isoxazol-5-one

: 178151-97-8
(3R,3aR,6aR)-2-Benzyl-3-((S)-1-benzyloxy-ethyl)-tetrahydro-furo[2,3-d]isoxazol-5-one

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; tetrabutyl ammonium fluoride; Yield given. Multistep reaction. Yields of byproduct given; 1.) CH₂Cl₂, -20 deg C, 20 min, 2.) THF, 10 min;
DOI:10.1016/0957-4166(96)00110-3

Reference yield:

: 29601-98-7
N-benzylhydroxylamine hydrochloride

: 177981-88-3
(3S,3aS,6aS)-2-Benzyl-3-((S)-1-benzyloxy-ethyl)-tetrahydro-furo[2,3-d]isoxazol-5-one

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / aq. AcONa / methanol / 0.5 h / Ambient temperature

2: 1.) TMSOTf, 2.) Bu₄NF / 1.) CH₂Cl₂, -20 deg C, 20 min, 2.) THF, 10 min

With trimethylsilyl trifluoromethanesulfonate; tetrabutyl ammonium fluoride; sodium acetate; In methanol;
DOI:10.1016/0957-4166(96)00110-3