3-chloro-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxybenzyl ester

Base Information

Chemical Name:3-chloro-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxybenzyl ester
CAS No.:139501-51-2
Molecular Formula:C₂₃H₂₁ClN₂O₅S
Molecular Weight:472.949
Hs Code.:

Synonyms:3-chloro-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxybenzyl ester

Suppliers and Price of 3-chloro-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxybenzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-chloro-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxybenzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-chloro-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxybenzyl ester

There total 10 articles about 3-chloro-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxybenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 139472-60-9
2-((2R,3R)-2-Benzenesulfonylsulfanyl-4-oxo-3-phenylacetylamino-azetidin-1-yl)-buta-2,3-dienoic acid 4-methoxy-benzyl ester

: 139501-51-2
3-chloro-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxybenzyl ester

Guidance literature:: With oxygen; lithium chloride; In various solvent(s); at 18 - 22 ℃; for 6h;
DOI:10.1246/bcsj.69.1391

Reference yield:

: 131857-34-6
(E)-2-((2R,3R)-2-Benzenesulfonylsulfanyl-4-oxo-3-phenylacetylamino-azetidin-1-yl)-4-chloro-3-hydroxy-but-2-enoic acid 4-methoxy-benzyl ester

: 139501-51-2
3-chloro-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxybenzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / Et₃N / CH₂Cl₂ / 1 h / -78 °C

2: 83 percent / LiCl, AlCl₃, N-methylpyrrolidine / 4 h / Ambient temperature

3: 2 percent Chromat_. / TiCl₄, Al, NMP / CH₂Cl₂ / 6.5 h / Ambient temperature

4: 71 percent / AlCl₃, LiCl, NMP / 2.5 h / Ambient temperature

With 1-Methylpyrrolidine; 1-methyl-pyrrolidin-2-one; aluminium trichloride; titanium tetrachloride; triethylamine; aluminium; lithium chloride; In dichloromethane;
DOI:10.1021/jo970051n

Reference yield:

: 168418-30-2
p-methoxybenzyl (E)-3-chloro-2-<2-oxo-3-(phenylacetamido)-4-<(phenylsulfonyl)thio>azetidin-1-yl>-4-<<(trifluoromethyl)sulfonyl>oxy>-2-butenoate

: 139501-51-2
3-chloro-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxybenzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / LiCl, AlCl₃, N-methylpyrrolidine / 4 h / Ambient temperature

2: 2 percent Chromat_. / TiCl₄, Al, NMP / CH₂Cl₂ / 6.5 h / Ambient temperature

3: 71 percent / AlCl₃, LiCl, NMP / 2.5 h / Ambient temperature

With 1-Methylpyrrolidine; 1-methyl-pyrrolidin-2-one; aluminium trichloride; titanium tetrachloride; aluminium; lithium chloride; In dichloromethane;
DOI:10.1021/jo970051n