3-(5'-O-tert-Butyldiphenylsilyl-2',3'-O-isopropylidene-β-D-ribofuranosyl)-8-hydrazino-6-(methylsulfanyl)imidazo[2,1-f][1,2,4]triazine

Base Information

Chemical Name:3-(5'-O-tert-Butyldiphenylsilyl-2',3'-O-isopropylidene-β-D-ribofuranosyl)-8-hydrazino-6-(methylsulfanyl)imidazo[2,1-f][1,2,4]triazine
CAS No.:254114-43-7
Molecular Formula:C₃₀H₃₈N₆O₄SSi
Molecular Weight:606.821
Hs Code.:

Synonyms:3-(5'-O-tert-Butyldiphenylsilyl-2',3'-O-isopropylidene-β-D-ribofuranosyl)-8-hydrazino-6-(methylsulfanyl)imidazo[2,1-f][1,2,4]triazine

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Chemical Property of 3-(5'-O-tert-Butyldiphenylsilyl-2',3'-O-isopropylidene-β-D-ribofuranosyl)-8-hydrazino-6-(methylsulfanyl)imidazo[2,1-f][1,2,4]triazine

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Technology Process of 3-(5'-O-tert-Butyldiphenylsilyl-2',3'-O-isopropylidene-β-D-ribofuranosyl)-8-hydrazino-6-(methylsulfanyl)imidazo[2,1-f][1,2,4]triazine

There total 6 articles about 3-(5'-O-tert-Butyldiphenylsilyl-2',3'-O-isopropylidene-β-D-ribofuranosyl)-8-hydrazino-6-(methylsulfanyl)imidazo[2,1-f][1,2,4]triazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 254114-42-6
3-(5'-O-tert-Butyldiphenylsilyl-2',3'-O-isopropylidene-β-D-ribofuranosyl)-6,8-bis(methylsulfanyl)imidazo[2,1-f][1,2,4]triazine

: 254114-43-7
3-(5'-O-tert-Butyldiphenylsilyl-2',3'-O-isopropylidene-β-D-ribofuranosyl)-8-hydrazino-6-(methylsulfanyl)imidazo[2,1-f][1,2,4]triazine

Guidance literature:: With hydrazine hydrate; In ethanol; for 1h; Heating;
DOI:10.1039/a904065j

Reference yield:

: 50-69-1
D-ribose

: 254114-43-7
3-(5'-O-tert-Butyldiphenylsilyl-2',3'-O-isopropylidene-β-D-ribofuranosyl)-8-hydrazino-6-(methylsulfanyl)imidazo[2,1-f][1,2,4]triazine

Guidance literature:: Multi-step reaction with 6 steps

1.1: 87 percent / HCl; H₂O; CuSO₄*H₂O / 37 °C

2.1: 75 percent / imidazole / CH₂Cl₂ / 24 h / 25 °C

3.1: benzene / 7 °C / Heating

3.2: 82 percent / DBU / benzene / 0.02 h / 20 °C

4.1: 58 percent / DIBAL-H / toluene / 0.25 h / -100 °C

5.1: 62 percent / HMPA / toluene / 18 h / 100 °C

6.1: 87 percent / N₂H₄*H₂O / ethanol / 1 h / Heating

With 1H-imidazole; hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; water; diisobutylaluminium hydride; hydrazine hydrate; copper(II) sulfate; In ethanol; dichloromethane; toluene; benzene; 1.1: Alkylation / 2.1: Etherification / 3.1: Condensation / 3.2: Cyclization / 4.1: Reduction / 5.1: Condensation / 6.1: Substitution;
DOI:10.1039/a904065j

Reference yield:

: 96690-02-7
5-O-(tert-butyldiphenylsilyl)-2,3-O-isopropylidene-D-ribofuranose

: 254114-43-7
3-(5'-O-tert-Butyldiphenylsilyl-2',3'-O-isopropylidene-β-D-ribofuranosyl)-8-hydrazino-6-(methylsulfanyl)imidazo[2,1-f][1,2,4]triazine

Guidance literature:: Multi-step reaction with 4 steps

1.1: benzene / 7 °C / Heating

1.2: 82 percent / DBU / benzene / 0.02 h / 20 °C

2.1: 58 percent / DIBAL-H / toluene / 0.25 h / -100 °C

3.1: 62 percent / HMPA / toluene / 18 h / 100 °C

4.1: 87 percent / N₂H₄*H₂O / ethanol / 1 h / Heating

With N,N,N,N,N,N-hexamethylphosphoric triamide; diisobutylaluminium hydride; hydrazine hydrate; In ethanol; toluene; benzene; 1.1: Condensation / 1.2: Cyclization / 2.1: Reduction / 3.1: Condensation / 4.1: Substitution;
DOI:10.1039/a904065j