Technology Process of (S*,R*)-N-<<2-amino>-3-<(triphenylmethyl)thio>propyl>-N-(benzyloxycarbonyl)-L-valyl>-1,2,3,4-tetrahydro-3-isoquinolinyl>carbonyl>-L-norleucine
There total 7 articles about (S*,R*)-N-<<2-amino>-3-<(triphenylmethyl)thio>propyl>-N-(benzyloxycarbonyl)-L-valyl>-1,2,3,4-tetrahydro-3-isoquinolinyl>carbonyl>-L-norleucine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium hydroxide;
In
tetrahydrofuran;
for 4h;
Ambient temperature;
DOI:10.1021/jm950642a
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1.) acetic acid, 2.) NaBH3CN / 1.) MeOH, RT, 30 min, 2.) MeOH, THF, RT, 2 h
2: 92 percent / diisopropylethylamine / CH2Cl2 / 16 h / 0 - 20 °C
3: 100 percent / 2 N LiOH / tetrahydrofuran; methanol / 16 h / Ambient temperature
4: 72 percent / N,N-diisopropylethylamine, Bop-Cl / CH2Cl2 / 16 h / 0 °C
5: 100 percent / 1 N LiOH / tetrahydrofuran; methanol / 16 h / Ambient temperature
6: 79 percent / N,N-diisopropylethylamine, Bop / acetonitrile; dimethylformamide / 16 h
7: 98 percent / 2 N LiOH / tetrahydrofuran / 4 h / Ambient temperature
With
lithium hydroxide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium cyanoborohydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm950642a
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1.) acetic acid, 2.) NaBH3CN / 1.) MeOH, RT, 30 min, 2.) MeOH, THF, RT, 2 h
2: 92 percent / diisopropylethylamine / CH2Cl2 / 16 h / 0 - 20 °C
3: 100 percent / 2 N LiOH / tetrahydrofuran; methanol / 16 h / Ambient temperature
4: 72 percent / N,N-diisopropylethylamine, Bop-Cl / CH2Cl2 / 16 h / 0 °C
5: 100 percent / 1 N LiOH / tetrahydrofuran; methanol / 16 h / Ambient temperature
6: 79 percent / N,N-diisopropylethylamine, Bop / acetonitrile; dimethylformamide / 16 h
7: 98 percent / 2 N LiOH / tetrahydrofuran / 4 h / Ambient temperature
With
lithium hydroxide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium cyanoborohydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm950642a
