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(S*,R*)-N-<<2-amino>-3-<(triphenylmethyl)thio>propyl>-N-(benzyloxycarbonyl)-L-valyl>-1,2,3,4-tetrahydro-3-isoquinolinyl>carbonyl>-L-norleucine

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  • Chemical Name:(S*,R*)-N-<<2-amino>-3-<(triphenylmethyl)thio>propyl>-N-(benzyloxycarbonyl)-L-valyl>-1,2,3,4-tetrahydro-3-isoquinolinyl>carbonyl>-L-norleucine
  • CAS No.:166169-52-4
  • Molecular Formula:C56H66N4O8S
  • Molecular Weight:955.228
  • Hs Code.:
  • Mol file:166169-52-4.mol
(S*,R*)-N-<<2-<N-<2-<<(1,1-dimethylethoxy)carbonyl>amino>-3-<(triphenylmethyl)thio>propyl>-N-(benzyloxycarbonyl)-L-valyl>-1,2,3,4-tetrahydro-3-isoquinolinyl>carbonyl>-L-norleucine

Synonyms:(S*,R*)-N-<<2-amino>-3-<(triphenylmethyl)thio>propyl>-N-(benzyloxycarbonyl)-L-valyl>-1,2,3,4-tetrahydro-3-isoquinolinyl>carbonyl>-L-norleucine

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Chemical Property of (S*,R*)-N-<<2-amino>-3-<(triphenylmethyl)thio>propyl>-N-(benzyloxycarbonyl)-L-valyl>-1,2,3,4-tetrahydro-3-isoquinolinyl>carbonyl>-L-norleucine Edit
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Technology Process of (S*,R*)-N-<<2-amino>-3-<(triphenylmethyl)thio>propyl>-N-(benzyloxycarbonyl)-L-valyl>-1,2,3,4-tetrahydro-3-isoquinolinyl>carbonyl>-L-norleucine

There total 7 articles about (S*,R*)-N-<<2-amino>-3-<(triphenylmethyl)thio>propyl>-N-(benzyloxycarbonyl)-L-valyl>-1,2,3,4-tetrahydro-3-isoquinolinyl>carbonyl>-L-norleucine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
Multi-step reaction with 7 steps
1: 1.) acetic acid, 2.) NaBH3CN / 1.) MeOH, RT, 30 min, 2.) MeOH, THF, RT, 2 h
2: 92 percent / diisopropylethylamine / CH2Cl2 / 16 h / 0 - 20 °C
3: 100 percent / 2 N LiOH / tetrahydrofuran; methanol / 16 h / Ambient temperature
4: 72 percent / N,N-diisopropylethylamine, Bop-Cl / CH2Cl2 / 16 h / 0 °C
5: 100 percent / 1 N LiOH / tetrahydrofuran; methanol / 16 h / Ambient temperature
6: 79 percent / N,N-diisopropylethylamine, Bop / acetonitrile; dimethylformamide / 16 h
7: 98 percent / 2 N LiOH / tetrahydrofuran / 4 h / Ambient temperature
With lithium hydroxide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium cyanoborohydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm950642a
Guidance literature:
Multi-step reaction with 7 steps
1: 1.) acetic acid, 2.) NaBH3CN / 1.) MeOH, RT, 30 min, 2.) MeOH, THF, RT, 2 h
2: 92 percent / diisopropylethylamine / CH2Cl2 / 16 h / 0 - 20 °C
3: 100 percent / 2 N LiOH / tetrahydrofuran; methanol / 16 h / Ambient temperature
4: 72 percent / N,N-diisopropylethylamine, Bop-Cl / CH2Cl2 / 16 h / 0 °C
5: 100 percent / 1 N LiOH / tetrahydrofuran; methanol / 16 h / Ambient temperature
6: 79 percent / N,N-diisopropylethylamine, Bop / acetonitrile; dimethylformamide / 16 h
7: 98 percent / 2 N LiOH / tetrahydrofuran / 4 h / Ambient temperature
With lithium hydroxide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium cyanoborohydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm950642a
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