6-[5-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenylaminocarbonyl)-2-methyl-phenoxy]-pyrimidin-4-carboxylic acid-methylamide

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Chemical Name:6-[5-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenylaminocarbonyl)-2-methyl-phenoxy]-pyrimidin-4-carboxylic acid-methylamide
CAS No.:1215029-06-3
Molecular Formula:C₂₆H₃₁N₅O₆S
Molecular Weight:541.628
Hs Code.:

Synonyms:6-[5-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenylaminocarbonyl)-2-methyl-phenoxy]-pyrimidin-4-carboxylic acid-methylamide

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Chemical Property of 6-[5-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenylaminocarbonyl)-2-methyl-phenoxy]-pyrimidin-4-carboxylic acid-methylamide

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Technology Process of 6-[5-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenylaminocarbonyl)-2-methyl-phenoxy]-pyrimidin-4-carboxylic acid-methylamide

There total 5 articles about 6-[5-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenylaminocarbonyl)-2-methyl-phenoxy]-pyrimidin-4-carboxylic acid-methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1215030-78-6
6-chloro-N-methylpyrimidine-4-carboxamide

: 1215030-19-5
N-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-3-hydroxy-4-methyl-benzamide

: 1215029-06-3
6-[5-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenylaminocarbonyl)-2-methyl-phenoxy]-pyrimidin-4-carboxylic acid-methylamide

Guidance literature:: With potassium tert-butylate; In N,N-dimethyl-formamide; at 20 ℃; for 20h; Inert atmosphere;

Reference yield:

: 1215030-28-6
3-benzyloxy-N-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-4-methyl-benzamide

: 1215029-06-3
6-[5-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenylaminocarbonyl)-2-methyl-phenoxy]-pyrimidin-4-carboxylic acid-methylamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 20 °C / 2585.81 Torr

2: potassium tert-butylate / N,N-dimethyl-formamide / 20 h / 20 °C / Inert atmosphere

With potassium tert-butylate; hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 695179-07-8
N-(3-amino-5-tert-butyl-2-methoxy-phenyl)-methanesulphonamide hydrochloride

: 1215029-06-3
6-[5-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenylaminocarbonyl)-2-methyl-phenoxy]-pyrimidin-4-carboxylic acid-methylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere

1.2: 50 °C

2.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 20 °C / 2585.81 Torr

3.1: potassium tert-butylate / N,N-dimethyl-formamide / 20 h / 20 °C / Inert atmosphere

With 1-hydroxy-7-aza-benzotriazole; potassium tert-butylate; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;