Chloromethyl-phenyl-phosphinic acid 2-hydroxy-phenyl ester

Base Information

• Chemical Name: Chloromethyl-phenyl-phosphinic acid 2-hydroxy-phenyl ester
• CAS No.: 125300-98-3
• Molecular Formula: C₁₃H₁₂ClO₃P
• Molecular Weight: 282.663
• Mol file: 125300-98-3.mol

Synonyms:Chloromethyl-phenyl-phosphinic acid 2-hydroxy-phenyl ester

Chemical Property of Chloromethyl-phenyl-phosphinic acid 2-hydroxy-phenyl ester

Chemical Property:

Purity/Quality:

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Technology Process of Chloromethyl-phenyl-phosphinic acid 2-hydroxy-phenyl ester

There total 1 articles about Chloromethyl-phenyl-phosphinic acid 2-hydroxy-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2-(chloromethyl)-1,3,2-benzodioxaphosphole 2-oxide (110606-89-8) + phenylmagnesium bromide → Chloromethyl-phenyl-phosphinic acid 2-hydroxy-phenyl ester (125300-98-3)

Guidance literature:

In tetrahydrofuran; diethyl ether; at 20 ℃; for 3h;

DOI:10.1007/BF00953305

Reference yield: 89.0%

Chloromethyl-phenyl-phosphinic acid 2-hydroxy-phenyl ester (125300-98-3) → 2,3-dihydro-2-phenyl-1,4,2-benzodioxaphosphorin 2-oxide (110607-12-0)

Guidance literature:

With triethylamine; In toluene; for 5h; Heating;

DOI:10.1007/BF00953305

Reference yield:

Chloromethyl-phenyl-phosphinic acid 2-hydroxy-phenyl ester (125300-98-3) → <(o-hydroxyphenyl)methyl>phenylphosphinic acid (110607-11-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / NEt₃ / toluene / 5 h / Heating

2: air / benzene; CHCl₃ / 72 h

With air; triethylamine; In chloroform; toluene; benzene;

DOI:10.1007/BF00953305

upstream raw materials:

2-(chloromethyl)-1,3,2-benzodioxaphosphole 2-oxide

Downstream raw materials:

2,3-dihydro-2-phenyl-1,4,2-benzodioxaphosphorin 2-oxide

<(o-hydroxyphenyl)methyl>phenylphosphinic acid