(1S,2R)-2-[4-(2-methylquinolin-4-ylmethoxyl)benzenesulfonylamino]cyclopentane carboxylic acid

Base Information

Chemical Name:(1S,2R)-2-[4-(2-methylquinolin-4-ylmethoxyl)benzenesulfonylamino]cyclopentane carboxylic acid
CAS No.:910331-90-7
Molecular Formula:C₂₃H₂₄N₂O₅S
Molecular Weight:440.52
Hs Code.:

Synonyms:(1S,2R)-2-[4-(2-methylquinolin-4-ylmethoxyl)benzenesulfonylamino]cyclopentane carboxylic acid

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Chemical Property of (1S,2R)-2-[4-(2-methylquinolin-4-ylmethoxyl)benzenesulfonylamino]cyclopentane carboxylic acid

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Technology Process of (1S,2R)-2-[4-(2-methylquinolin-4-ylmethoxyl)benzenesulfonylamino]cyclopentane carboxylic acid

There total 7 articles about (1S,2R)-2-[4-(2-methylquinolin-4-ylmethoxyl)benzenesulfonylamino]cyclopentane carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 910331-90-7
(1S,2R)-2-[4-(2-methylquinolin-4-ylmethoxyl)benzenesulfonylamino]cyclopentane carboxylic acid

Guidance literature:

Reference yield:

: 4-chloromethyl-2-methylquinoline hydrochloride salt

: 910331-90-7
(1S,2R)-2-[4-(2-methylquinolin-4-ylmethoxyl)benzenesulfonylamino]cyclopentane carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / water / 0.17 h / Inert atmosphere; Large scale

1.2: 24.25 h / 55 - 60 °C / Inert atmosphere; Large scale

2.1: thionyl chloride / 1,2-dichloro-ethane; N,N-dimethyl-formamide / 4 h / 70 - 80 °C / Inert atmosphere; Large scale

3.1: 4-methyl-morpholine / 5 - 21 °C / Large scale

With 4-methyl-morpholine; thionyl chloride; sodium hydroxide; In water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/op800090s

Reference yield:

: 4-(2-methylquinolin-4-ylmethoxy)benzenesulfonic acid

: 910331-90-7
(1S,2R)-2-[4-(2-methylquinolin-4-ylmethoxyl)benzenesulfonylamino]cyclopentane carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 1,2-dichloro-ethane; N,N-dimethyl-formamide / 4 h / 70 - 80 °C / Inert atmosphere; Large scale

2: 4-methyl-morpholine / 5 - 21 °C / Large scale

With 4-methyl-morpholine; thionyl chloride; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/op800090s