methyl 1-(1-(6-((trans)-4-tert-butylcyclohexyloxy)quinolin-2-yl)ethyl)azetidine-3-carboxylate

Base Information

• Chemical Name: methyl 1-(1-(6-((trans)-4-tert-butylcyclohexyloxy)quinolin-2-yl)ethyl)azetidine-3-carboxylate
• CAS No.: 1266119-18-9
• Molecular Formula: C₂₆H₃₆N₂O₃
• Molecular Weight: 424.583

Synonyms:methyl 1-(1-(6-((trans)-4-tert-butylcyclohexyloxy)quinolin-2-yl)ethyl)azetidine-3-carboxylate

Chemical Property of methyl 1-(1-(6-((trans)-4-tert-butylcyclohexyloxy)quinolin-2-yl)ethyl)azetidine-3-carboxylate

Chemical Property:

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Technology Process of methyl 1-(1-(6-((trans)-4-tert-butylcyclohexyloxy)quinolin-2-yl)ethyl)azetidine-3-carboxylate

There total 2 articles about methyl 1-(1-(6-((trans)-4-tert-butylcyclohexyloxy)quinolin-2-yl)ethyl)azetidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

1-(6-((trans)-4-tert-butylcyclohexyloxy)quinolin-2-yl)ethanone (1266119-14-5) + methyl azetidine-3-carboxylate (343238-58-4) → methyl 1-(1-(6-((trans)-4-tert-butylcyclohexyloxy)quinolin-2-yl)ethyl)azetidine-3-carboxylate (1266119-18-9)

Guidance literature:

1-(6-((trans)-4-tert-butylcyclohexyloxy)quinolin-2-yl)ethanone; methyl azetidine-3-carboxylate; In ethanol; for 2h; Reflux;

With ethanol; sodium cyanoborohydride; at 20 ℃; for 1h; Reflux;

Reference yield:

C25H33N2O3(1-)*Li(1+) → methyl 1-(1-(6-((trans)-4-tert-butylcyclohexyloxy)quinolin-2-yl)ethyl)azetidine-3-carboxylate (1266119-18-9)

Guidance literature:

With citric acid;

Reference yield:

methyl 1-(1-(6-((trans)-4-tert-butylcyclohexyloxy)quinolin-2-yl)ethyl)azetidine-3-carboxylate (1266119-18-9) → C25H33N2O3(1-)*Li(1+)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃;

upstream raw materials:

1-(6-((trans)-4-tert-butylcyclohexyloxy)quinolin-2-yl)ethanone

methyl azetidine-3-carboxylate

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