(+/-)-[2,2-Bis(benzyloxymethyl)-3,3-difluorcyclopropyl]-1,2,3,4-tetrahydro-2,4-pyrimidindion

Base Information

Chemical Name:(+/-)-[2,2-Bis(benzyloxymethyl)-3,3-difluorcyclopropyl]-1,2,3,4-tetrahydro-2,4-pyrimidindion
CAS No.:512813-21-7
Molecular Formula:C₂₃H₂₂F₂N₂O₄
Molecular Weight:428.435
Hs Code.:

Synonyms:(+/-)-[2,2-Bis(benzyloxymethyl)-3,3-difluorcyclopropyl]-1,2,3,4-tetrahydro-2,4-pyrimidindion

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Chemical Property of (+/-)-[2,2-Bis(benzyloxymethyl)-3,3-difluorcyclopropyl]-1,2,3,4-tetrahydro-2,4-pyrimidindion

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Technology Process of (+/-)-[2,2-Bis(benzyloxymethyl)-3,3-difluorcyclopropyl]-1,2,3,4-tetrahydro-2,4-pyrimidindion

There total 5 articles about (+/-)-[2,2-Bis(benzyloxymethyl)-3,3-difluorcyclopropyl]-1,2,3,4-tetrahydro-2,4-pyrimidindion which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: (+/-)-{[2,2-Bis(benzyloxymethyl)-3,3-difluorcyclopropyl]-(3-ethoxy-crotonyl)}-harnstoff

: 512813-21-7
(+/-)-[2,2-Bis(benzyloxymethyl)-3,3-difluorcyclopropyl]-1,2,3,4-tetrahydro-2,4-pyrimidindion

Guidance literature:: With sulfuric acid; In propan-1-ol; at 85 ℃; for 1.5h;
DOI:10.1515/znb-2002-1115

Reference yield:

: [2,2-bis(benzyloxymethyl)-3,3-difluoro-cyclopropyl]methanol

: 512813-21-7
(+/-)-[2,2-Bis(benzyloxymethyl)-3,3-difluorcyclopropyl]-1,2,3,4-tetrahydro-2,4-pyrimidindion

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / 2,2,6,6-tetramethylpiperidine-N-oxyl; KBr; aq. NaOCl / NaHCO₃ / CH₂Cl₂ / 0.25 h / 10 - 15 °C / pH 9.5

2: Et₃N / acetone / 0.5 h / -5 °C

3: 2.92 g / aq. NaN₃ / acetone / 1 h / 0 °C

4: 77 percent / toluene / 85 °C

5: 55 percent / aq. H₂SO₄ / propan-1-ol / 1.5 h / 85 °C

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium azide; sulfuric acid; triethylamine; potassium bromide; sodium hydrogencarbonate; In propan-1-ol; dichloromethane; acetone; toluene;
DOI:10.1515/znb-2002-1115

Reference yield:

: 512813-12-6
(+/-)-2,2-Bis(benzyloxymethyl)-3,3-difluor-cyclopropancarbonsauere

: 512813-21-7
(+/-)-[2,2-Bis(benzyloxymethyl)-3,3-difluorcyclopropyl]-1,2,3,4-tetrahydro-2,4-pyrimidindion

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / acetone / 0.5 h / -5 °C

2: 2.92 g / aq. NaN₃ / acetone / 1 h / 0 °C

3: 77 percent / toluene / 85 °C

4: 55 percent / aq. H₂SO₄ / propan-1-ol / 1.5 h / 85 °C

With sodium azide; sulfuric acid; triethylamine; In propan-1-ol; acetone; toluene;
DOI:10.1515/znb-2002-1115