Ethyl 2-[4-[3-[4-[4-(4-methoxyphenyl)piperazin-1-ylmethyl]-2-(4-trifluoromethylphenyl)-5-thiazolyl]propionyl]-2-methylphenoxy]propionate

Base Information

Chemical Name:Ethyl 2-[4-[3-[4-[4-(4-methoxyphenyl)piperazin-1-ylmethyl]-2-(4-trifluoromethylphenyl)-5-thiazolyl]propionyl]-2-methylphenoxy]propionate
CAS No.:915715-92-3
Molecular Formula:C₃₇H₄₀F₃N₃O₅S
Molecular Weight:695.803
Hs Code.:

Synonyms:Ethyl 2-[4-[3-[4-[4-(4-methoxyphenyl)piperazin-1-ylmethyl]-2-(4-trifluoromethylphenyl)-5-thiazolyl]propionyl]-2-methylphenoxy]propionate

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Chemical Property of Ethyl 2-[4-[3-[4-[4-(4-methoxyphenyl)piperazin-1-ylmethyl]-2-(4-trifluoromethylphenyl)-5-thiazolyl]propionyl]-2-methylphenoxy]propionate

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Technology Process of Ethyl 2-[4-[3-[4-[4-(4-methoxyphenyl)piperazin-1-ylmethyl]-2-(4-trifluoromethylphenyl)-5-thiazolyl]propionyl]-2-methylphenoxy]propionate

There total 2 articles about Ethyl 2-[4-[3-[4-[4-(4-methoxyphenyl)piperazin-1-ylmethyl]-2-(4-trifluoromethylphenyl)-5-thiazolyl]propionyl]-2-methylphenoxy]propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 915715-91-2
1-(4-Hydroxy-3-methylphenyl)-3-[4-[4-(4-methoxyphenyl)piperazin-1-ylmethyl]-2-(4-trifluoromethylphenyl)-thiazol-5-yl]propan-1-one

: 535-11-5,41978-69-2
Ethyl 2-bromopropionate

: 915715-92-3
Ethyl 2-[4-[3-[4-[4-(4-methoxyphenyl)piperazin-1-ylmethyl]-2-(4-trifluoromethylphenyl)-5-thiazolyl]propionyl]-2-methylphenoxy]propionate

Guidance literature:: With potassium carbonate; In acetone; at 20 ℃; for 20h;

Reference yield:

: C₃₆H₃₆F₃NO₆S

: 915715-92-3
Ethyl 2-[4-[3-[4-[4-(4-methoxyphenyl)piperazin-1-ylmethyl]-2-(4-trifluoromethylphenyl)-5-thiazolyl]propionyl]-2-methylphenoxy]propionate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; water; acetic acid / 20 h / Heating / reflux

2: tetrahydrofuran / 20 h / Heating / reflux

3: potassium carbonate / acetone / 20 h / 20 °C

With hydrogenchloride; water; potassium carbonate; acetic acid; In tetrahydrofuran; acetone;

Reference yield: 80.0%

: 915715-92-3
Ethyl 2-[4-[3-[4-[4-(4-methoxyphenyl)piperazin-1-ylmethyl]-2-(4-trifluoromethylphenyl)-5-thiazolyl]propionyl]-2-methylphenoxy]propionate

: 2-[4-[3-[4-[4-(4-Methoxyphenyl)piperazin-1-ylmethyl]-2-(4-trifluoromethylphenyl)-5-thiazolyl]propionyl]-2-methylphenoxy]propionic acid

Guidance literature:: Ethyl 2-[4-[3-[4-[4-(4-methoxyphenyl)piperazin-1-ylmethyl]-2-(4-trifluoromethylphenyl)-5-thiazolyl]propionyl]-2-methylphenoxy]propionate; With lithium hydroxide; water; In ethanol; for 2h; Heating / reflux;

With hydrogenchloride; In ethanol; water; pH=5 - 6;