1-(2'-deoxy-5'-O-tert-butyldiphenylsilyl-β-D-erythro-pentofuranosyl)-4-fluoroindole

Base Information

Chemical Name:1-(2'-deoxy-5'-O-tert-butyldiphenylsilyl-β-D-erythro-pentofuranosyl)-4-fluoroindole
CAS No.:943524-14-9
Molecular Formula:C₂₉H₃₂FNO₃Si
Molecular Weight:489.662
Hs Code.:

Synonyms:1-(2'-deoxy-5'-O-tert-butyldiphenylsilyl-β-D-erythro-pentofuranosyl)-4-fluoroindole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(2'-deoxy-5'-O-tert-butyldiphenylsilyl-β-D-erythro-pentofuranosyl)-4-fluoroindole

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Technology Process of 1-(2'-deoxy-5'-O-tert-butyldiphenylsilyl-β-D-erythro-pentofuranosyl)-4-fluoroindole

There total 6 articles about 1-(2'-deoxy-5'-O-tert-butyldiphenylsilyl-β-D-erythro-pentofuranosyl)-4-fluoroindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 882043-80-3
1-(2'-deoxy-β-D-erythro-pentofuranosyl)-4-fluoroindole

: 58479-61-1
tert-butylchlorodiphenylsilane

: 943524-14-9
1-(2'-deoxy-5'-O-tert-butyldiphenylsilyl-β-D-erythro-pentofuranosyl)-4-fluoroindole

Guidance literature:: With pyridine; at 20 ℃; for 24h;
DOI:10.1139/V07-020

Reference yield:

: 399-68-8
4-fluoro-1H-indole-2-carboxylic acid

: 943524-14-9
1-(2'-deoxy-5'-O-tert-butyldiphenylsilyl-β-D-erythro-pentofuranosyl)-4-fluoroindole

Guidance literature:: Multi-step reaction with 4 steps

1: 58 percent / copper; N-methylpyrrolidinone / 240 °C

2: 94 percent / NaH / acetonitrile / 0.33 h / 20 °C

3: 97 percent / MeONa; methanol / 2 h / 20 °C

4: 87 percent / pyridine / 24 h / 20 °C

With pyridine; 1-methyl-pyrrolidin-2-one; methanol; sodium methylate; copper; sodium hydride; In acetonitrile;
DOI:10.1139/V07-020

Reference yield:

: 387-43-9
4-fluoroindole

: 943524-14-9
1-(2'-deoxy-5'-O-tert-butyldiphenylsilyl-β-D-erythro-pentofuranosyl)-4-fluoroindole

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / NaH / acetonitrile / 0.33 h / 20 °C

2: 97 percent / MeONa; methanol / 2 h / 20 °C

3: 87 percent / pyridine / 24 h / 20 °C

With pyridine; methanol; sodium methylate; sodium hydride; In acetonitrile;
DOI:10.1139/V07-020