4-[4-(6-cyanopyridin-3-yl)-9H-carbazol-9-yl]-2-[(3-hydroxypropyl)amino]benzoic acid

Base Information

Chemical Name:4-[4-(6-cyanopyridin-3-yl)-9H-carbazol-9-yl]-2-[(3-hydroxypropyl)amino]benzoic acid
CAS No.:1190424-15-7
Molecular Formula:C₂₈H₂₂N₄O₃
Molecular Weight:462.508
Hs Code.:

Synonyms:4-[4-(6-cyanopyridin-3-yl)-9H-carbazol-9-yl]-2-[(3-hydroxypropyl)amino]benzoic acid

Suppliers and Price of 4-[4-(6-cyanopyridin-3-yl)-9H-carbazol-9-yl]-2-[(3-hydroxypropyl)amino]benzoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of 4-[4-(6-cyanopyridin-3-yl)-9H-carbazol-9-yl]-2-[(3-hydroxypropyl)amino]benzoic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-[4-(6-cyanopyridin-3-yl)-9H-carbazol-9-yl]-2-[(3-hydroxypropyl)amino]benzoic acid

There total 6 articles about 4-[4-(6-cyanopyridin-3-yl)-9H-carbazol-9-yl]-2-[(3-hydroxypropyl)amino]benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1190424-14-6
2-methylpropan-2-yl 4-[4-(6-cyanopyridin-3-yl)-9H-carbazol-9-yl]-2-[(3-hydroxypropyl)-amino]benzoate

: 1190424-15-7
4-[4-(6-cyanopyridin-3-yl)-9H-carbazol-9-yl]-2-[(3-hydroxypropyl)amino]benzoic acid

Guidance literature:: With hydrogenchloride; water; In 1,4-dioxane; at 100 ℃; for 2h; microwave irradiation;

Reference yield:

: 52602-39-8
9H-carbazol-4-ol

: 1190424-15-7
4-[4-(6-cyanopyridin-3-yl)-9H-carbazol-9-yl]-2-[(3-hydroxypropyl)amino]benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 24 h / 20 °C / Inert atmosphere

2: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 4 h / Inert atmosphere; Reflux

3: caesium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 4.5 h / Inert atmosphere; Reflux

4: potassium carbonate / dimethyl sulfoxide / 1.5 h / 90 °C / microwave irradiation

5: hydrogenchloride; water / 1,4-dioxane / 2 h / 100 °C / microwave irradiation

With hydrogenchloride; water; potassium carbonate; caesium carbonate; triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 889858-12-2
4-bromo-2-fluoro-benzoic acid tert-butyl ester

: 1190424-15-7
4-[4-(6-cyanopyridin-3-yl)-9H-carbazol-9-yl]-2-[(3-hydroxypropyl)amino]benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 4.5 h / Inert atmosphere; Reflux

2: potassium carbonate / dimethyl sulfoxide / 1.5 h / 90 °C / microwave irradiation

3: hydrogenchloride; water / 1,4-dioxane / 2 h / 100 °C / microwave irradiation

With hydrogenchloride; water; potassium carbonate; caesium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; dimethyl sulfoxide;