(RS)-1,4-Dihydro-6-methyl-4-(2-nitrophenyl)pyridazin-3,5-dicarbonsaeure-3-ethyl-5-methylester

Base Information

Chemical Name:(RS)-1,4-Dihydro-6-methyl-4-(2-nitrophenyl)pyridazin-3,5-dicarbonsaeure-3-ethyl-5-methylester
CAS No.:180676-75-9
Molecular Formula:C₁₆H₁₇N₃O₆
Molecular Weight:347.327
Hs Code.:

Synonyms:(RS)-1,4-Dihydro-6-methyl-4-(2-nitrophenyl)pyridazin-3,5-dicarbonsaeure-3-ethyl-5-methylester

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Chemical Property of (RS)-1,4-Dihydro-6-methyl-4-(2-nitrophenyl)pyridazin-3,5-dicarbonsaeure-3-ethyl-5-methylester

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Technology Process of (RS)-1,4-Dihydro-6-methyl-4-(2-nitrophenyl)pyridazin-3,5-dicarbonsaeure-3-ethyl-5-methylester

There total 4 articles about (RS)-1,4-Dihydro-6-methyl-4-(2-nitrophenyl)pyridazin-3,5-dicarbonsaeure-3-ethyl-5-methylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.0%

: (2R,3R)-2-Hydroxy-5-methyl-3-(2-nitro-phenyl)-2,3-dihydro-furan-2,4-dicarboxylic acid 2-ethyl ester 4-methyl ester

: 180676-75-9
(RS)-1,4-Dihydro-6-methyl-4-(2-nitrophenyl)pyridazin-3,5-dicarbonsaeure-3-ethyl-5-methylester

: 180676-76-0
1-Amino-5-methyl-3-(2-nitrophenyl)pyrrol-2,4-dicarbonsaeure-2-ethyl-4-methylester

Guidance literature:: With hydrazine hydrate; In acetic acid; for 1h; Heating;

Reference yield:

: 39562-27-1
methyl 2-(2'-nitrobenzylidene)acetoacetate

: 180676-75-9
(RS)-1,4-Dihydro-6-methyl-4-(2-nitrophenyl)pyridazin-3,5-dicarbonsaeure-3-ethyl-5-methylester

Guidance literature:: Multi-step reaction with 3 steps

1: 68 percent / iPr₂NH, 15percent nBuLi / tetrahydrofuran; hexane / 1.5 h / -78 °C

2: 81 percent / NBS / acetonitrile / 1) 0 deg C, 30 min, 2) r.t., 1 h

3: 52 percent / N₂H₄*H₂O / acetic acid / 1 h / Heating

With N-Bromosuccinimide; n-butyllithium; hydrazine hydrate; diisopropylamine; In tetrahydrofuran; hexane; acetic acid; acetonitrile;

Reference yield:

: 180676-71-5
2-[2-Methoxycarbonyl-1-(2-nitro-phenyl)-3-oxo-butyl]-[1,3]dithiolane-2-carboxylic acid ethyl ester

: 180676-75-9
(RS)-1,4-Dihydro-6-methyl-4-(2-nitrophenyl)pyridazin-3,5-dicarbonsaeure-3-ethyl-5-methylester

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / NBS / acetonitrile / 1) 0 deg C, 30 min, 2) r.t., 1 h

2: 52 percent / N₂H₄*H₂O / acetic acid / 1 h / Heating

With N-Bromosuccinimide; hydrazine hydrate; In acetic acid; acetonitrile;