Technology Process of allyl (E,4R,5S)-4-(methoxymethoxy)-5-(trityloxy)hex-2-enoate
There total 7 articles about allyl (E,4R,5S)-4-(methoxymethoxy)-5-(trityloxy)hex-2-enoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
allyl (E,5S)-4-hydroxy-5-(trityloxy)hex-2-enoate;
With
dmap; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 0 ℃;
for 0.25h;
Inert atmosphere;
chloromethyl methyl ether;
In
dichloromethane;
at 0 - 20 ℃;
Inert atmosphere;
DOI:10.1016/j.tet.2011.04.099
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: caesium carbonate / acetonitrile / 0.75 h / 20 °C / Inert atmosphere
1.2: 0.5 h / -15 °C / Inert atmosphere
2.1: cerium(III) chloride heptahydrate / methanol / 0.75 h / 20 °C / Inert atmosphere
2.2: 2.17 h / -40 °C / Inert atmosphere
2.3: -40 - 20 °C / Inert atmosphere
3.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere
3.2: 0 - 20 °C / Inert atmosphere
4.1: potassium carbonate / 2 h / 20 °C / Inert atmosphere
5.1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 0 °C / Inert atmosphere
5.2: 0 - 20 °C / Inert atmosphere
With
dmap; cerium(III) chloride heptahydrate; di-isopropyl azodicarboxylate; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine;
In
tetrahydrofuran; methanol; dichloromethane; acetonitrile;
1.2: Wittig-Horner reaction / 3.1: Mitsunobu reaction / 3.2: Mitsunobu reaction;
DOI:10.1016/j.tet.2011.04.099
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: cerium(III) chloride heptahydrate / methanol / 0.75 h / 20 °C / Inert atmosphere
1.2: 2.17 h / -40 °C / Inert atmosphere
1.3: -40 - 20 °C / Inert atmosphere
2.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere
2.2: 0 - 20 °C / Inert atmosphere
3.1: potassium carbonate / 2 h / 20 °C / Inert atmosphere
4.1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 0 °C / Inert atmosphere
4.2: 0 - 20 °C / Inert atmosphere
With
dmap; cerium(III) chloride heptahydrate; di-isopropyl azodicarboxylate; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine;
In
tetrahydrofuran; methanol; dichloromethane;
2.1: Mitsunobu reaction / 2.2: Mitsunobu reaction;
DOI:10.1016/j.tet.2011.04.099
