Technology Process of 6-[4-(biphenyl-4-ylmethyl)piperazin-1-yl]-3,4-dihydroquinazolin-2(1H)-one
There total 10 articles about 6-[4-(biphenyl-4-ylmethyl)piperazin-1-yl]-3,4-dihydroquinazolin-2(1H)-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
6-(piperazin-1-yl)-3,4-dihydroquinazolin-2(1H)-one; 4-Phenylbenzaldehyde;
With
triethylamine;
In
dimethyl sulfoxide;
at 0 - 20 ℃;
for 0.5h;
With
sodium tris(acetoxy)borohydride;
In
dimethyl sulfoxide;
for 6h;
- Guidance literature:
-
6-(piperazin-1-yl)-3,4-dihydroquinazolin-2(1H)-one trifluoroacetic acid salt; 4-Phenylbenzaldehyde;
With
triethylamine;
In
dimethyl sulfoxide;
at 0 - 20 ℃;
With
sodium tris(acetoxy)borohydride;
In
dimethyl sulfoxide;
at 20 ℃;
for 6h;
DOI:10.14233/ajchem.2014.15639
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: pyridine / 12 h / 20 °C
2.1: tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 8 h / 110 °C / Inert atmosphere
3.1: hydrogen / ethanol / 6 h / 1034.32 Torr
4.1: water; potassium hydroxide / ethanol / 12 h / 90 °C
5.1: tetrahydrofuran / 6 h / 80 °C
6.1: tetrahydrofuran; dichloromethane / 0 - 20 °C
7.1: triethylamine / dimethyl sulfoxide / 0 - 20 °C
7.2: 6 h / 20 °C
With
pyridine; tris-(dibenzylideneacetone)dipalladium(0); water; hydrogen; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; potassium hydroxide;
In
tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; toluene;
2.1: |Buchwald-Hartwig Coupling;
DOI:10.14233/ajchem.2014.15639
