((E)-(S)-1-(2-Benzyloxy-ethyl)-7-{2-[3-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-propyl]-[1,3]dithian-2-yl}-4-methyl-hept-4-enyloxy)-tert-butyl-dimethyl-silane

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Chemical Name:((E)-(S)-1-(2-Benzyloxy-ethyl)-7-{2-[3-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-propyl]-[1,3]dithian-2-yl}-4-methyl-hept-4-enyloxy)-tert-butyl-dimethyl-silane
CAS No.:900519-21-3
Molecular Formula:C₃₅H₆₀O₄S₂Si
Molecular Weight:637.077
Hs Code.:

Synonyms:((E)-(S)-1-(2-Benzyloxy-ethyl)-7-{2-[3-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-propyl]-[1,3]dithian-2-yl}-4-methyl-hept-4-enyloxy)-tert-butyl-dimethyl-silane

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Chemical Property of ((E)-(S)-1-(2-Benzyloxy-ethyl)-7-{2-[3-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-propyl]-[1,3]dithian-2-yl}-4-methyl-hept-4-enyloxy)-tert-butyl-dimethyl-silane

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Technology Process of ((E)-(S)-1-(2-Benzyloxy-ethyl)-7-{2-[3-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-propyl]-[1,3]dithian-2-yl}-4-methyl-hept-4-enyloxy)-tert-butyl-dimethyl-silane

There total 11 articles about ((E)-(S)-1-(2-Benzyloxy-ethyl)-7-{2-[3-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-propyl]-[1,3]dithian-2-yl}-4-methyl-hept-4-enyloxy)-tert-butyl-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 900519-18-8
[(E)-(S)-1-(2-Benzyloxy-ethyl)-7-iodo-4-methyl-hept-4-enyloxy]-tert-butyl-dimethyl-silane

: 900519-20-2
(R)-4-(3-[1,3]Dithian-2-yl-propyl)-2,2-dimethyl-[1,3]dioxolane

: 900519-21-3
((E)-(S)-1-(2-Benzyloxy-ethyl)-7-{2-[3-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-propyl]-[1,3]dithian-2-yl}-4-methyl-hept-4-enyloxy)-tert-butyl-dimethyl-silane

Guidance literature:: With tert.-butyl lithium; In tetrahydrofuran; pentane; at -78 - 0 ℃;
DOI:10.1021/ja0618954

Reference yield:

: (E)-(S)-9-Benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-4-methyl-non-3-en-1-ol

: 900519-21-3
((E)-(S)-1-(2-Benzyloxy-ethyl)-7-{2-[3-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-propyl]-[1,3]dithian-2-yl}-4-methyl-hept-4-enyloxy)-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / PPh₃; imidazole; I₂ / CH₂Cl₂ / 2 h / 20 °C

2: 72 percent / tBuLi / tetrahydrofuran; pentane / -78 - 0 °C

With 1H-imidazole; iodine; tert.-butyl lithium; triphenylphosphine; In tetrahydrofuran; dichloromethane; pentane;
DOI:10.1021/ja0618954

Reference yield:

: 900519-17-7
2,2-Dimethyl-propionic acid (E)-(S)-9-benzyloxy-7-(tert-butyl-dimethyl-silanyloxy)-4-methyl-non-3-enyl ester

: 900519-21-3
((E)-(S)-1-(2-Benzyloxy-ethyl)-7-{2-[3-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-propyl]-[1,3]dithian-2-yl}-4-methyl-hept-4-enyloxy)-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 3 steps

1: 14.21 g / DIBAL / CH₂Cl₂; toluene / 0.25 h / -78 °C

2: 100 percent / PPh₃; imidazole; I₂ / CH₂Cl₂ / 2 h / 20 °C

3: 72 percent / tBuLi / tetrahydrofuran; pentane / -78 - 0 °C

With 1H-imidazole; iodine; tert.-butyl lithium; diisobutylaluminium hydride; triphenylphosphine; In tetrahydrofuran; dichloromethane; toluene; pentane;
DOI:10.1021/ja0618954