1-<<2'-(tert-butoxycarbonyl)biphenyl-4-yl>methyl>-2-butyl-5-<<(2-methoxyethoxy)methoxy>methyl>-4-(trifluoromethyl)imidazole

Base Information

Chemical Name:1-<<2'-(tert-butoxycarbonyl)biphenyl-4-yl>methyl>-2-butyl-5-<<(2-methoxyethoxy)methoxy>methyl>-4-(trifluoromethyl)imidazole
CAS No.:114772-63-3
Molecular Formula:C₃₁H₃₉F₃N₂O₅
Molecular Weight:576.656
Hs Code.:

Synonyms:1-<<2'-(tert-butoxycarbonyl)biphenyl-4-yl>methyl>-2-butyl-5-<<(2-methoxyethoxy)methoxy>methyl>-4-(trifluoromethyl)imidazole

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Chemical Property of 1-<<2'-(tert-butoxycarbonyl)biphenyl-4-yl>methyl>-2-butyl-5-<<(2-methoxyethoxy)methoxy>methyl>-4-(trifluoromethyl)imidazole

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Technology Process of 1-<<2'-(tert-butoxycarbonyl)biphenyl-4-yl>methyl>-2-butyl-5-<<(2-methoxyethoxy)methoxy>methyl>-4-(trifluoromethyl)imidazole

There total 13 articles about 1-<<2'-(tert-butoxycarbonyl)biphenyl-4-yl>methyl>-2-butyl-5-<<(2-methoxyethoxy)methoxy>methyl>-4-(trifluoromethyl)imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 57598-33-1
2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline

: 114772-63-3
1-<<2'-(tert-butoxycarbonyl)biphenyl-4-yl>methyl>-2-butyl-5-<<(2-methoxyethoxy)methoxy>methyl>-4-(trifluoromethyl)imidazole

Guidance literature:: Multi-step reaction with 8 steps

1: tetrahydrofuran / 2 h / 20 °C

2: 88 percent / 4.5 N aq. HCl / 12 h / Heating

3: oxalyl chloride / CH₂Cl₂ / 3 h / 25 °C

4: tetrahydrofuran / 1 h / 25 °C

5: N-bromosuccinimide, dibenzoyl peroxide / CCl₄ / 3 h / Heating

6: 1.) sodium methoxide / 1.) DMF, 25 deg C, 0.25 h, 2.) DMF, 40 deg C, 4 h

7: 1.) n-BuLi, t-butyl alcohol / 1.) THF, 0 deg C, 2.) 25 deg C, 16 h

8: 1.) cadimium, 2.) hexamethylphosphoric triamide, copper(I) bromide / 1.) DMF, 25 deg C, 2 h, 2.) DMF, 70-75 deg C, 6 h

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; N-Bromosuccinimide; n-butyllithium; oxalyl dichloride; sodium methylate; copper(I) bromide; cadmium; tert-butyl alcohol; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; dichloromethane;
DOI:10.1021/jm00112a031

Reference yield:

: 7148-03-0
o-tolylbenzoic acid

: 114772-63-3
1-<<2'-(tert-butoxycarbonyl)biphenyl-4-yl>methyl>-2-butyl-5-<<(2-methoxyethoxy)methoxy>methyl>-4-(trifluoromethyl)imidazole

Guidance literature:: Multi-step reaction with 6 steps

1: oxalyl chloride / CH₂Cl₂ / 3 h / 25 °C

2: tetrahydrofuran / 1 h / 25 °C

3: N-bromosuccinimide, dibenzoyl peroxide / CCl₄ / 3 h / Heating

4: 1.) sodium methoxide / 1.) DMF, 25 deg C, 0.25 h, 2.) DMF, 40 deg C, 4 h

5: 1.) n-BuLi, t-butyl alcohol / 1.) THF, 0 deg C, 2.) 25 deg C, 16 h

6: 1.) cadimium, 2.) hexamethylphosphoric triamide, copper(I) bromide / 1.) DMF, 25 deg C, 2 h, 2.) DMF, 70-75 deg C, 6 h

With N,N,N,N,N,N-hexamethylphosphoric triamide; N-Bromosuccinimide; n-butyllithium; oxalyl dichloride; sodium methylate; copper(I) bromide; cadmium; tert-butyl alcohol; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; dichloromethane;
DOI:10.1021/jm00112a031

Reference yield:

: 114772-35-9
4'-methylbiphenyl-2-carboxylic acid chloride

: 114772-63-3
1-<<2'-(tert-butoxycarbonyl)biphenyl-4-yl>methyl>-2-butyl-5-<<(2-methoxyethoxy)methoxy>methyl>-4-(trifluoromethyl)imidazole

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / 1 h / 25 °C

2: N-bromosuccinimide, dibenzoyl peroxide / CCl₄ / 3 h / Heating

3: 1.) sodium methoxide / 1.) DMF, 25 deg C, 0.25 h, 2.) DMF, 40 deg C, 4 h

4: 1.) n-BuLi, t-butyl alcohol / 1.) THF, 0 deg C, 2.) 25 deg C, 16 h

5: 1.) cadimium, 2.) hexamethylphosphoric triamide, copper(I) bromide / 1.) DMF, 25 deg C, 2 h, 2.) DMF, 70-75 deg C, 6 h

With N,N,N,N,N,N-hexamethylphosphoric triamide; N-Bromosuccinimide; n-butyllithium; sodium methylate; copper(I) bromide; cadmium; tert-butyl alcohol; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane;
DOI:10.1021/jm00112a031