5-bromo-2'-deoxyuridine 5'-ethyl>glycyl ester> dihydrochloride

Base Information

Chemical Name:5-bromo-2'-deoxyuridine 5'-ethyl>glycyl ester> dihydrochloride
CAS No.:130328-09-5
Molecular Formula:C₂₁H₃₃BrN₄O₆*2ClH
Molecular Weight:590.342
Hs Code.:

5-bromo-2'-deoxyuridine 5'-<N-<2-<(2-cyclohexylethyl)amino>ethyl>glycyl ester> dihydrochloride

Synonyms:5-bromo-2'-deoxyuridine 5'-ethyl>glycyl ester> dihydrochloride

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Chemical Property of 5-bromo-2'-deoxyuridine 5'-ethyl>glycyl ester> dihydrochloride

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Technology Process of 5-bromo-2'-deoxyuridine 5'-ethyl>glycyl ester> dihydrochloride

There total 5 articles about 5-bromo-2'-deoxyuridine 5'-ethyl>glycyl ester> dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 130328-08-4
5-bromo-2'-deoxyuridine 5'-ethyl>glycyl ester>

: 130328-09-5
5-bromo-2'-deoxyuridine 5'-ethyl>glycyl ester> dihydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 0 - 25 ℃; for 0.75h;
DOI:10.1021/jm00171a038

Reference yield:

: 10258-93-2
N-(2-cyclohexyl-ethyl)-ethylenediamine

: 130328-09-5
5-bromo-2'-deoxyuridine 5'-ethyl>glycyl ester> dihydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 11.1 g / H₂ / 5percent Pd/C / ethanol; H₂O / 2016.9 Torr / Ambient temperature

2: NaOH / H₂O; tetrahydrofuran / Ambient temperature

3: 1.) NaH / 1.) DMF, 50 deg C, 15 min, 2.) 80 deg C, 20 h

4: 75 percent / HClgas / ethyl acetate / 0.75 h / 0 - 25 °C

With hydrogenchloride; sodium hydroxide; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; ethanol; water; ethyl acetate;
DOI:10.1021/jm00171a038

Reference yield:

: 130327-95-6
N-(2-(2-Cyclohexylethylamino)ethyl)glycine

: 130328-09-5
5-bromo-2'-deoxyuridine 5'-ethyl>glycyl ester> dihydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: NaOH / H₂O; tetrahydrofuran / Ambient temperature

2: 100 percent / 4-(dimethylamino)pyridine, dicyclohexylcarbodiimide / CH₂Cl₂ / Ambient temperature

3: 66 percent / HOAc, H₂O / 1.5 h / 60 °C

4: 75 percent / HClgas / ethyl acetate / 0.75 h / 0 - 25 °C

With hydrogenchloride; dmap; sodium hydroxide; water; acetic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; water; ethyl acetate;
DOI:10.1021/jm00171a038