(R)-N-((2-methoxyphenyl)(phenyl)methyl)-4-methylbenzenesulfonamide

Base Information

• Chemical Name: (R)-N-((2-methoxyphenyl)(phenyl)methyl)-4-methylbenzenesulfonamide
• CAS No.: 898269-04-0
• Molecular Formula: C₂₁H₂₁NO₃S
• Molecular Weight: 367.469
• Mol file: 898269-04-0.mol

Synonyms:(R)-N-((2-methoxyphenyl)(phenyl)methyl)-4-methylbenzenesulfonamide

Chemical Property of (R)-N-((2-methoxyphenyl)(phenyl)methyl)-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (R)-N-((2-methoxyphenyl)(phenyl)methyl)-4-methylbenzenesulfonamide

There total 4 articles about (R)-N-((2-methoxyphenyl)(phenyl)methyl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N-(2-methoxybenzylidene)-p-toluenesulfonamide (100200-70-2) + phenylboronic acid (98-80-6) → (R)-N-((2-methoxyphenyl)(phenyl)methyl)-4-methylbenzenesulfonamide (898269-04-0)

Guidance literature:

With potassium fluoride; chlorobis(ethylene)rhodium(I) dimer; C₂₈H₂₆O₅S; In water; toluene; at 50 ℃; enantioselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1039/c9ra04836g

Reference yield: 94.0%

triphenylboroxine (3262-89-3) + N-(2-methoxybenzylidene)-p-toluenesulfonamide (100200-70-2) → (R)-N-((2-methoxyphenyl)(phenyl)methyl)-4-methylbenzenesulfonamide (898269-04-0)

Guidance literature:

With 2C₂₉H₂₆NP*Cl₂Rh₂; potassium hydroxide; In 1,4-dioxane; water; at 60 ℃; for 6h; optical yield given as %ee; enantioselective reaction;

DOI:10.1039/c1cc11823d

Reference yield:

N-(2-methoxyphenyl)methylidene-4-methylbenzenesulfonamide (100200-70-2) + phenylboronic acid (98-80-6) → (R)-N-((2-methoxyphenyl)(phenyl)methyl)-4-methylbenzenesulfonamide (898269-04-0) + (S)-N-((2-methoxyphenyl)(phenyl)methyl)-4-methylbenzenesulfonamide (258277-17-7)

Guidance literature:

With potassium fluoride; chiral spiro monophosphite ligand; bis(ethylene)rhodium acetylacetonate; In water; toluene; at 35 ℃; for 20h; Title compound not separated from byproducts;

DOI:10.1021/ol060755w

upstream raw materials:

N-(2-methoxyphenyl)methylidene-4-methylbenzenesulfonamide

phenylboronic acid

N-(2-methoxybenzylidene)-p-toluenesulfonamide

triphenylboroxine